Title:
METHOD FOR PRODUCING HYDROGEL, METHOD FOR ENVELOPING ENVELOPMENT TARGET, AND METHOD FOR RELEASING ENVELOPMENT TARGET
Document Type and Number:
WIPO Patent Application WO/2015/159995
Kind Code:
A1
Abstract:
Provided is a method for producing a hydrogel, which enables a hydrogel comprising polyethylene glycol to be produced under low peroxidase concentration conditions and physiological conditions. The method for producing a hydrogel involves crosslinking polyethylene glycol having two or more thiol groups using peroxidase in the presence of a phenol compound.
Inventors:
KAMIYA NORIHO (JP)
MORIYAMA KOSUKE (JP)
MINAMIHATA KOSUKE (JP)
MORIYAMA KOSUKE (JP)
MINAMIHATA KOSUKE (JP)
Application Number:
PCT/JP2015/062458
Publication Date:
October 22, 2015
Filing Date:
April 16, 2015
Export Citation:
Assignee:
KAMIYA NORIHO (JP)
MORIYAMA KOSUKE (JP)
HITACHI ALOKA MEDICAL LTD (JP)
MORIYAMA KOSUKE (JP)
HITACHI ALOKA MEDICAL LTD (JP)
International Classes:
C12P11/00; A61K47/34; C08G75/14
Domestic Patent References:
| WO2010087912A1 | 2010-08-05 |
Foreign References:
| EP2597110A1 | 2013-05-29 | |||
| JP2011173887A | 2011-09-08 |
Other References:
SMRITI SINGH: "Embedding of Active Proteins and Living Cells in Redox-Sensitive Hydrogels and Nanogels through Enzymatic Cross-Linking", ANGEW. CHEM. INT. ED., vol. 52, no. 10, 2013, pages 3000 - 3003, XP055231453, ISSN: 1433-7851
DETCHO A. STOYANOVSKY: "Phenoxyl Radical-Induced Thiol-Dependent Generation of Reactive Oxygen Species: Implications for Benzene Toxicity", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 317, no. 2, 1995, pages 315 - 323, XP055231455
RADOSLAV GOLDMAN: "Reduction of Phenoxyl Radicals by Thioredoxin Results in Selective Oxidation of Its SH-Groups to Disulfides.", AN ANTIOXIDANT FUNCTION OF THIOREDOXIN, BIOCHEMISTRY, vol. 34, 1995, pages 4765 - 4772, XP055231456
LARRY J KRICKA: "Synthesis and Characterization of 4-Iodophenylboronic Acid: A New Enhancer for the Horseradish Peroxidase-Catalyzed Chemiluminescent Oxidation of Luminol", ANALYTICAL BIOCHEMISTRY, vol. 240, 1996, pages 119 - 125, XP001183202, ISSN: 0003-2697
DETCHO A. STOYANOVSKY: "Phenoxyl Radical-Induced Thiol-Dependent Generation of Reactive Oxygen Species: Implications for Benzene Toxicity", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 317, no. 2, 1995, pages 315 - 323, XP055231455
RADOSLAV GOLDMAN: "Reduction of Phenoxyl Radicals by Thioredoxin Results in Selective Oxidation of Its SH-Groups to Disulfides.", AN ANTIOXIDANT FUNCTION OF THIOREDOXIN, BIOCHEMISTRY, vol. 34, 1995, pages 4765 - 4772, XP055231456
LARRY J KRICKA: "Synthesis and Characterization of 4-Iodophenylboronic Acid: A New Enhancer for the Horseradish Peroxidase-Catalyzed Chemiluminescent Oxidation of Luminol", ANALYTICAL BIOCHEMISTRY, vol. 240, 1996, pages 119 - 125, XP001183202, ISSN: 0003-2697
Attorney, Agent or Firm:
YKI Patent Attorneys (JP)
Patent business corporation YKI international patent firm (JP)
Patent business corporation YKI international patent firm (JP)
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