Title:
METHOD FOR PRODUCING N-[4-METHYLAMINOBENZOYL]-L-GLUTAMIC ACID DIETHYL ESTER
Document Type and Number:
WIPO Patent Application WO/2024/028999
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for efficiently producing an N-[4-methylaminobenzoyl]-L-glutamic acid diethyl ester, which is a pharmaceutical intermediate. In this method for producing an N-[4-methylaminobenzoyl]-L-glutamic acid diethyl ester, 4-aminobenozic acid protected with an inexpensive nitrobenzenesulfonyl group is used as a starting material and N-monomethylated in an inexpensive and simple manner. Thus, the skeleton is constructed by a minimum number of steps with the inexpensive reagent.
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Inventors:
TAKEHARA JUN (JP)
Application Number:
PCT/JP2022/029737
Publication Date:
February 08, 2024
Filing Date:
August 03, 2022
Export Citation:
Assignee:
ILS INC (JP)
International Classes:
C07C311/21; C07C231/14
Foreign References:
| JPS61282368A | 1986-12-12 | |||
| JPH05339268A | 1993-12-21 |
Other References:
SANTI DANIEL V.: "Syntheses of some analogs of a possible intermediate formed in the thymidylate synthetase reaction", JOURNAL OF HETEROCYCLIC CHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 4, no. 4, 1 December 1967 (1967-12-01), US , pages 475 - 481, XP093134685, ISSN: 0022-152X, DOI: 10.1002/jhet.5570040403
MAGERLEIN BARNEY J, WEISBLAT DAVID I: "£-[(2-Amino-4-hydrc>xy-6-pteridylmethyl)-j%nitrobenzenesulfonylamino ]-benzoic Acid and Intermediates", JOURNAL OF AMERICAN CHEMICAL SOCIET, vol. 46, no. 6, 20 March 1954 (1954-03-20), pages 1702 - 1703, XP093134686
MAGERLEIN BARNEY J, WEISBLAT DAVID I: "£-[(2-Amino-4-hydrc>xy-6-pteridylmethyl)-j%nitrobenzenesulfonylamino ]-benzoic Acid and Intermediates", JOURNAL OF AMERICAN CHEMICAL SOCIET, vol. 46, no. 6, 20 March 1954 (1954-03-20), pages 1702 - 1703, XP093134686
Attorney, Agent or Firm:
SIKS & CO. (JP)
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