Title:
METHOD FOR PRODUCING N-ACETYL-D-GLUCOSAMINE AND/OR D-GLUCOSAMINE HYDROCHLORIDE BY MICROBIAL FERMENTATION
Document Type and Number:
WIPO Patent Application WO/2017/174036
Kind Code:
A1
Abstract:
A method for producing N-acetyl-D-glucosamine and/or D-glucosamine hydrochloride by means of microbial fermentation. By expressing a vitreoscilla hemoglobin in a microorganism, N-acetyl-D-glucosamine and/or D-glucosamine hydrochloride are produced with higher efficiency and higher yield.
Inventors:
SUN LAN (CN)
Application Number:
PCT/CN2017/080649
Publication Date:
October 12, 2017
Filing Date:
April 14, 2017
Export Citation:
Assignee:
SUN LAN (CN)
International Classes:
C12P19/26; C12N1/21; C12P19/02; C12R1/19
Domestic Patent References:
| WO2004003175A2 | 2004-01-08 |
Foreign References:
| CN104059872A | 2014-09-24 | |||
| CN104293724A | 2015-01-21 | |||
| US6372457B1 | 2002-04-16 |
Other References:
HAO, NING ET AL.: "Effect of Expressing vgb Gene and Hyaluronic Acid Synthesis Operon (has) in Streptococcus zooepidemicus on Cell Growth and Production of Hyaluronic Acid", CHINA BIOTECHNOLOGY, vol. 25, no. 6, 31 December 2005 (2005-12-31), pages 56 - 60, XP009514094, ISSN: 1671-8135, DOI: 10.3969/j.issn.1671-8135.2005.06.012
DATABASE NCBI [O] 3 June 2015 (2015-06-03), "hemoglobin [Vitreoscilla stercoraria]", XP055431080, retrieved from NCBI Database accession no. WP_019959060.1
DATABASE GenBank [O] 8 June 2009 (2009-06-08), LEOPOLD, S.R. ET AL.: "Escherichia coli strain 493/89 putative N-acetylmannosamine kinase (ECs4095) gene, complete cds", XP055428031, retrieved from NCBI Database accession no. EU_894695.1
DATABASE NCBI [O] 6 October 2015 (2015-10-06), NONE: "MULTISPECIES: N-acetylmannosamine-6-P epimerase [Proteobacteria]", XP055428035, retrieved from NCBI Database accession no. WP _ 000054239.1
DATABASE GenBank [O] 6 June 2013 (2013-06-06), WEINSTOCK, G. ET AL.: "UDP-N-acetylglucosamine 2-epimerase [Escherichia coli MS 175-1]", XP055427915, retrieved from NCBI Database accession no. EFJ67649. 1
See also references of EP 3441473A4
DATABASE NCBI [O] 3 June 2015 (2015-06-03), "hemoglobin [Vitreoscilla stercoraria]", XP055431080, retrieved from NCBI Database accession no. WP_019959060.1
DATABASE GenBank [O] 8 June 2009 (2009-06-08), LEOPOLD, S.R. ET AL.: "Escherichia coli strain 493/89 putative N-acetylmannosamine kinase (ECs4095) gene, complete cds", XP055428031, retrieved from NCBI Database accession no. EU_894695.1
DATABASE NCBI [O] 6 October 2015 (2015-10-06), NONE: "MULTISPECIES: N-acetylmannosamine-6-P epimerase [Proteobacteria]", XP055428035, retrieved from NCBI Database accession no. WP _ 000054239.1
DATABASE GenBank [O] 6 June 2013 (2013-06-06), WEINSTOCK, G. ET AL.: "UDP-N-acetylglucosamine 2-epimerase [Escherichia coli MS 175-1]", XP055427915, retrieved from NCBI Database accession no. EFJ67649. 1
See also references of EP 3441473A4
Attorney, Agent or Firm:
HYLANDS LAW FIRM (CN)
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