Title:
METHOD FOR PRODUCING NOVEL HIPSC BY MEANS OF SIRNA INTRODUCTION
Document Type and Number:
WIPO Patent Application WO/2012/008301
Kind Code:
A1
Abstract:
Disclosed is a novel compound which induces pluripotent stem cells. Also disclosed is a novel anti-malignant tumor substance. Specifically disclosed is a pluripotent stem cell inducer for inducing cells into pluripotent stem cells, which contains one or more kinds of single-stranded polynucleotides or double-stranded polynucleotides that are selected from the group consisting of: (a) a single-stranded polynucleotide or double-stranded polynucleotide that comprises the nucleotide sequence set forth in SEQ ID NO: 1 or a nucleotide sequence that is produced by deleting, substituting or adding one to three nucleotides in the nucleotide sequence set forth in SEQ ID NO: 1; (b) a single-stranded polynucleotide or double-stranded polynucleotide that comprises the nucleotide sequence set forth in SEQ ID NO: 2 or a nucleotide sequence that is produced by deleting, substituting or adding one to three nucleotides in the nucleotide sequence set forth in SEQ ID NO: 2; and (c) a single-stranded polynucleotide or double-stranded polynucleotide that comprises the nucleotide sequence set forth in SEQ ID NO: 3 or a nucleotide sequence that is produced by deleting, substituting or adding one to three nucleotides in the nucleotide sequence set forth in SEQ ID NO: 3.
Inventors:
MIURA NORIMASA (JP)
Application Number:
PCT/JP2011/064846
Publication Date:
January 19, 2012
Filing Date:
June 28, 2011
Export Citation:
Assignee:
NAT UNIV CORP TOTTORI UNIV (JP)
MIURA NORIMASA (JP)
MIURA NORIMASA (JP)
International Classes:
C12N15/113; A61K31/7105; A61K31/713; A61K38/00; A61K48/00; A61P35/00; A61P43/00; C12N5/0775; C12N5/10; C12N15/09; C12N15/11
Domestic Patent References:
| WO2006112239A1 | 2006-10-26 | |||
| WO2009057831A1 | 2009-05-07 | |||
| WO2006137514A1 | 2006-12-28 | |||
| WO2010058819A1 | 2010-05-27 |
Other References:
WAKA SHINODA ET AL.: "Tei Bunka na Gan Saibo no Akusei Keishitsu o Soshitsu saseru miRNA-gun no Iyaku Oyo o Misueta in vitro Kento", JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY, vol. 40, 18 November 2009 (2009-11-18), pages S190, XP008168534
KUMIKO TEI ET AL., RNAI JIKKEN NARUHODO Q&A, 1 October 2006 (2006-10-01), pages 88 - 96, XP008169714
MIKA SHIMIZU ET AL.: "Hatsugan o Seigyo suru Shinki non-coding RNA Idenshi no in vivo ni Okeru Kento", JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY, vol. 38, 15 November 2007 (2007-11-15), pages S295, XP008168536
TAKAHASHI K. ET AL.: "Induction of pluripotent stem cells from adult human fibroblasts by defined factors.", CELL, vol. 131, no. 5, 2007, pages 861 - 872, XP008155962
See also references of EP 2594643A4
KUMIKO TEI ET AL., RNAI JIKKEN NARUHODO Q&A, 1 October 2006 (2006-10-01), pages 88 - 96, XP008169714
MIKA SHIMIZU ET AL.: "Hatsugan o Seigyo suru Shinki non-coding RNA Idenshi no in vivo ni Okeru Kento", JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY, vol. 38, 15 November 2007 (2007-11-15), pages S295, XP008168536
TAKAHASHI K. ET AL.: "Induction of pluripotent stem cells from adult human fibroblasts by defined factors.", CELL, vol. 131, no. 5, 2007, pages 861 - 872, XP008155962
See also references of EP 2594643A4
Attorney, Agent or Firm:
SK INTELLECTUAL PROPERTY LAW FIRM et al. (JP)
SK patent business corporation (JP)
SK patent business corporation (JP)
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