Title:
METHOD FOR PRODUCING OPTICALLY PURE L-/D-LACTIDE WITH ALL-GREEN CLOSED CYCLE PROCESS
Document Type and Number:
WIPO Patent Application WO/2018/176884
Kind Code:
A1
Abstract:
Disclosed is a method for producing optically pure L-/D-lactide with an all-green closed cycle process, with an aqueous L-/D-lactic acid solution and polylactic acid, which is produced as a by-product, being used as raw materials, wherein first, a dehydration oligomerization reaction is carried out to obtain an L-/D-lactic acid oligomer, then, L-/D-lactide is synthesised under the catalysis of a ternary composite catalytic system, wherein the synthesised product achieves optical purity without further purification being required; and the polylactic acid, which is produced as a by-product, is directly mixed with the aqueous L-/D-lactic acid solution to carry out a further dehydration oligomerization reaction, thereby achieving recycling. Advantages: the L-/D-lactic acid monomer has a high utilization rate (95-97%); the ternary composite catalyst has a high catalytic activity, is reusable, and has a high stereospecificity and selectivity; the use of a rectification purification process involving a great number of column plates and a plurality of columns is avoided; and the reaction temperature of the lactide synthesis procedure is lower than that of conventional processes, thereby reducing the energy consumption of production.
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Inventors:
LI HONG (CN)
ZHANG QUANXING (CN)
WANG ZIYU (CN)
HE WENWEN (CN)
HUANG WEI (CN)
JIANG WEI (CN)
LI AIMIN (CN)
ZHANG QUANXING (CN)
WANG ZIYU (CN)
HE WENWEN (CN)
HUANG WEI (CN)
JIANG WEI (CN)
LI AIMIN (CN)
Application Number:
PCT/CN2017/113588
Publication Date:
October 04, 2018
Filing Date:
November 29, 2017
Export Citation:
Assignee:
NANJING UNIVERSITY OF TECHNOLOGY (CN)
International Classes:
C07D319/12
Domestic Patent References:
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| WO2010005235A2 | 2010-01-14 |
Foreign References:
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| CN102911347A | 2013-02-06 | |||
| CN102863420A | 2013-01-09 | |||
| US20150239863A1 | 2015-08-27 |
Other References:
SUN, QIMEI ET AL.: "Current situation and progress of synthesis technology for L-lactide", CHEMICAL INDUSTRY AND ENGINEERING PROGRESS, vol. 34, no. 3, 31 December 2015 (2015-12-31), pages 802 - 809
CHENG, NA: "Green synthesis of enantiomerically pure lactide using biogenic creatinine catalyst", 31 May 2014, NANJING UNIVERSITY MASTER'S DISSERTATION, China, pages: 14 - 30
YOU, XINQIANG ET AL.: "Study on High-Yield technology of Lactide Preparation", WORLD SCI-TECH R & D, vol. 35, no. 2, 30 April 2013 (2013-04-30), pages 223 - 227
CHENG, NA: "Green synthesis of enantiomerically pure lactide using biogenic creatinine catalyst", 31 May 2014, NANJING UNIVERSITY MASTER'S DISSERTATION, China, pages: 14 - 30
YOU, XINQIANG ET AL.: "Study on High-Yield technology of Lactide Preparation", WORLD SCI-TECH R & D, vol. 35, no. 2, 30 April 2013 (2013-04-30), pages 223 - 227
Attorney, Agent or Firm:
SHENZHEN DISI-ELITE INTELLECTUAL PROPERTY AGENCY (CN)
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