METHOD OF PRODUCING POTASSIUM [18F] FLUORIDE AND QUATERNARY AMMONIUM [18F] FLUORIDE AND METHOD OF PRODUCING RADIOACTIVE FLUORINE-LABELED ORGANIC COMPOUND BY USING THE SAME

Title:

METHOD OF PRODUCING POTASSIUM [18F] FLUORIDE AND QUATERNARY AMMONIUM [18F] FLUORIDE AND METHOD OF PRODUCING RADIOACTIVE FLUORINE-LABELED ORGANIC COMPOUND BY USING THE SAME

Document Type and Number:

WIPO Patent Application WO/2006/068015

Kind Code:

A1

Abstract:

[PROBLEMS] To prevent the formation of impurities caused by the decomposition of a substrate in the process of producing a radioactive fluorine-labeled compound. [MEANS FOR SOLVING PROBLEMS] A method of producing potassium [¹⁸F] fluoride or quaternary ammonium [¹⁸F] fluoride characterized by comprising the step of contacting ¹⁸O-concentrated water containing [¹⁸F] fluoride ion with a strongly acidic cation exchange resin and thus removing cationic impurities, the next step of contacting the ¹⁸O-concentrated water with a weakly basic anion exchange resin and thus allowing the weakly basic anion exchange resin to adsorb the [¹⁸F] fluoride ion, and the step of eluting the [¹⁸F] fluoride ion having been adsorbed by the weakly basic anion exchange resin with the use of an aqueous solution of a potassium salt (excluding potassium carbonate and potassium hydrogencarbonate) or a solution of a quaternary ammonium salt (excluding hydrogen carbonate). A method of producing a radioactive fluorine-labeled organic compound which involves the step of labeling an organic compound with the use of the potassium [¹⁸F] fluoride or quaternary ammonium [¹⁸F] fluoride obtained by the above-described production method.

Inventors:

ITO OSAMU (JP)
KUROSAKI FUMIE (JP)
TOYAMA MASAHITO (JP)

Application Number:

PCT/JP2005/022947

Publication Date:

June 29, 2006

Filing Date:

December 14, 2005

Export Citation:

Click for automatic bibliography generation Help

Assignee:

NIHON MEDIPHYSICS CO LTD (JP)
ITO OSAMU (JP)
KUROSAKI FUMIE (JP)
TOYAMA MASAHITO (JP)

International Classes:

C01D3/02; A61K51/00; C01B7/19; C01B9/08; C01D3/16; C07B59/00; C07C211/63

Foreign References:

JPH11295494A	1999-10-29
JPS6163628A	1986-04-01

Other References:

SHLYER D.J. ET AL.: "Separation of (18F)Fluoride from (18O)Water using anion exchange resin", APPLIED RADIATION AND ISOTOPES, vol. 41, no. 6, 1990, pages 531 - 533, XP000127913

Attorney, Agent or Firm:

Ide, Masatake (9F Gobancho Grand Bldg., 3-1, Gobanch, Chiyoda-ku Tokyo 76, JP)

Download PDF:

View/Download PDF PDF Help

Previous Patent: RUBBER COMPOSITION AND PNEUMATIC TIRE USING SAME

Next Patent: STAMPER ATTACHING APPARATUS AND THERMAL TRANSFER PRESS MACHINE