Title:
METHOD FOR PRODUCING REDUCED COENZYME Q10 CRYSTALS OF FORM II OR CRYSTALLINE SOLID THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/202213
Kind Code:
A1
Abstract:
The purpose of the present disclosure is to provide a method for efficiently obtaining reduced coenzyme Q10 crystals of Form II that is a stable crystal form, particularly reduced coenzyme Q10 crystals of Form II having excellent oxidation stability, or a crystalline solid thereof. An embodiment of the present invention is a method for producing reduced coenzyme Q10 crystals of Form II or a crystalline solid thereof, comprising: adding a reduced coenzyme Q10 crystal of Form II as a seed crystal to a liquid mixture containing an alcohol and reduced coenzyme Q10; and precipitating reduced coenzyme Q10 crystals of Form II in the liquid mixture after the addition of the seed crystal. In the precipitation, during not less than 70% of the time in the period in which formazin turbidity units (FTUs) increase from 1,000 to 10,000, the rate of change in FTUs is maintained at not more than 45 FTU/min.
Inventors:
TANIZAKI SUBARU (JP)
ONO TADAO (JP)
HASHIMOTO TAKANORI (JP)
ONO TADAO (JP)
HASHIMOTO TAKANORI (JP)
Application Number:
PCT/JP2022/009360
Publication Date:
September 29, 2022
Filing Date:
March 04, 2022
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C07C41/40; C07C43/23; C07C50/28
Domestic Patent References:
| WO2020045571A1 | 2020-03-05 | |||
| WO2020067275A1 | 2020-04-02 | |||
| WO2012176842A1 | 2012-12-27 | |||
| WO2021161807A1 | 2021-08-19 |
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
Download PDF: