Title:
METHOD OF PRODUCING TETRACYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/050241
Kind Code:
A1
Abstract:
The present invention relates to a method of producing 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidine-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile. The method is industrially suitable and is capable of obtaining a desired substance safer and more easily and with higher yield than conventional methods.
Inventors:
SERIZAWA HIROKI (JP)
KAWASE AKIRA (JP)
FUKUDA HIROSHI (JP)
HAMA NAOTO (JP)
KAWASE AKIRA (JP)
FUKUDA HIROSHI (JP)
HAMA NAOTO (JP)
Application Number:
PCT/JP2019/034543
Publication Date:
March 12, 2020
Filing Date:
September 03, 2019
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D401/04; C07B61/00
Domestic Patent References:
| WO2017073706A1 | 2017-05-04 | |||
| WO2010143664A1 | 2010-12-16 |
Foreign References:
| JP2012126711A | 2012-07-05 | |||
| US20170247352A1 | 2017-08-31 | |||
| CN107033124A | 2017-08-11 | |||
| JP4588121B1 | 2010-11-24 | |||
| JPS4918630B1 | 1974-05-11 | |||
| JPS506987B1 | 1975-03-19 | |||
| JP5859712B1 | 2016-02-10 | |||
| JP2012126711A | 2012-07-05 |
Other References:
NATURE, vol. 448, 2007, pages 561 - 566
NEUROPSYCHOPHARMACOLOGY, vol. 33, 2008, pages 685 - 700
MOUADDIB ET AL., HETEROCYCLES, vol. 51, 1999, pages 2127
BORCH ET AL., J. AM. CHEM. SOC., vol. 93, 1971, pages 2897
JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 46, no. 2, 2009, pages 172 - 177
ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 18, no. 1, 2014, pages 89 - 102
SYNTHESIS, vol. 18, 2008, pages 2943 - 2952
TETRAHEDRON, vol. 64, no. 40, 2008, pages 9607 - 9618
ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 3, no. 2, 2005, pages 213 - 215
JOURNAL OF ORGANIC CHEMISTRY, vol. 58, no. 19, 1993, pages 5209 - 5220
GAZZETTA CHIMICA ITALIANA, vol. 121, no. 11, 1991, pages 499 - 504
SYNLETT, vol. 17, 2008, pages 2689 - 2691
BUCHWALD ET AL., ORGANIC SYNTHESIS, vol. 78, pages 23
COLL., vol. 10, pages 423
GREENEWUTS: "Protective Groups in Organic Synthesis", 2014, JOHN WILEY & SONS
See also references of EP 3848361A4
NEUROPSYCHOPHARMACOLOGY, vol. 33, 2008, pages 685 - 700
MOUADDIB ET AL., HETEROCYCLES, vol. 51, 1999, pages 2127
BORCH ET AL., J. AM. CHEM. SOC., vol. 93, 1971, pages 2897
JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 46, no. 2, 2009, pages 172 - 177
ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 18, no. 1, 2014, pages 89 - 102
SYNTHESIS, vol. 18, 2008, pages 2943 - 2952
TETRAHEDRON, vol. 64, no. 40, 2008, pages 9607 - 9618
ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 3, no. 2, 2005, pages 213 - 215
JOURNAL OF ORGANIC CHEMISTRY, vol. 58, no. 19, 1993, pages 5209 - 5220
GAZZETTA CHIMICA ITALIANA, vol. 121, no. 11, 1991, pages 499 - 504
SYNLETT, vol. 17, 2008, pages 2689 - 2691
BUCHWALD ET AL., ORGANIC SYNTHESIS, vol. 78, pages 23
COLL., vol. 10, pages 423
GREENEWUTS: "Protective Groups in Organic Synthesis", 2014, JOHN WILEY & SONS
See also references of EP 3848361A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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