Title:
METHOD FOR PRODUCING TRIAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/035766
Kind Code:
A1
Abstract:
Provided is a method whereby a triazole derivative having a (1,3-dioxan-5-yl)thio group of improved qualities can be produced at an elevated yield by using an industrially more advantageous operation while reducing impact on the environment. Also provided is a triazole derivative having a high purity.
Sodium hydroxide or sodium ethoxide is used in a reaction between an epoxide and a thioester. Hydrochloride of a diol compound is reacted with an aldehyde in the presence of trimethylsilyl chloride together with an organic base and in the presence or absence of an alcohol. Further, sodium methoxide is used in a coupling reaction between a phosphonic acid ester and an aldehyde.
Inventors:
KISHI NAOYUKI
IKEUCHI YUTAKA
SAITO TOMONORI
HARA MANABU
TAKAHASHI OSAMU
IKEUCHI YUTAKA
SAITO TOMONORI
HARA MANABU
TAKAHASHI OSAMU
Application Number:
PCT/JP2009/066583
Publication Date:
April 01, 2010
Filing Date:
September 25, 2009
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
KISHI NAOYUKI
IKEUCHI YUTAKA
SAITO TOMONORI
HARA MANABU
TAKAHASHI OSAMU
KISHI NAOYUKI
IKEUCHI YUTAKA
SAITO TOMONORI
HARA MANABU
TAKAHASHI OSAMU
International Classes:
C07D405/12; A61K31/4196; A61P31/10; C07C253/30; C07C255/56
Foreign References:
| JPH08333350A | 1996-12-17 | |||
| JP2000044547A | 2000-02-15 | |||
| JPH10279567A | 1998-10-20 | |||
| JPH10158167A | 1998-06-16 | |||
| JP2001348384A | 2001-12-18 | |||
| JP2002161035A | 2002-06-04 | |||
| JP2003335777A | 2003-11-28 | |||
| JP2002212180A | 2002-07-31 | |||
| JP2004323433A | 2004-11-18 |
Other References:
OIDA, S.: "Synthesis and antifungal activities of R-102557 and related dioxane-triazole derivatives", CHEM PHARM BULL (TOKYO), vol. 48, no. 5, 2000, pages 694 - 707
KAGOSHIMA, Y.: "Substituent effect of fluorine atoms in the 2,4-difluorophenyl group on antifungal activity of CS-758", JOURNAL OF FLUORINE CHEMISTRY, vol. 127, no. 12, 2006, pages 643 - 650
KONOSU, T. ET AL.: "Synthesis and in vitro antifungal activities of novel triazole antifungal agent CS-758", CHEM PHARM BULL (TOKYO), vol. 49, no. 12, 2001, pages 1647 - 1650
MAKOTO OKAWARA ET AL., GOSEI SHIYAKU, 1980, pages 50
KAGOSHIMA, Y.: "Substituent effect of fluorine atoms in the 2,4-difluorophenyl group on antifungal activity of CS-758", JOURNAL OF FLUORINE CHEMISTRY, vol. 127, no. 12, 2006, pages 643 - 650
KONOSU, T. ET AL.: "Synthesis and in vitro antifungal activities of novel triazole antifungal agent CS-758", CHEM PHARM BULL (TOKYO), vol. 49, no. 12, 2001, pages 1647 - 1650
MAKOTO OKAWARA ET AL., GOSEI SHIYAKU, 1980, pages 50
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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