Title:
A METHOD FOR THE PRODUCTION OF BIOADHESIVE COMPACT MATRICES
Document Type and Number:
WIPO Patent Application WO/2010/028826
Kind Code:
A3
Abstract:
A method for the preparation of a bioadhesive compact matrix, which comprises the preparation of a uniform mixture of powders comprising one alkylcellulose or one hydroxy alkylcellulose and a non- water- soluble, water- swellable cross-linked polycarboxylic polymer; the preparation of compressed units starting from such powder mixture by direct compression and finally the heating of the compressed units thus obtained to a temperature in the range of 80 - 250°C for a time of 1-60 minutes; the powder mixture can also comprise at least one active substance and the compressed units thus obtained are characterized by a prolonged release, and have a release kinetics of the active substance substantially of zero order in an aqueous solution at pH 4-8.
Inventors:
CAVIGLIOLI GABRIELE (IT)
PARODI BRUNELLA (IT)
RUSSO ELEONORA (IT)
CAFAGGI SERGIO (IT)
BIGNARDI GAETANO (IT)
CIRRINCIONE PAOLA (IT)
PARODI BRUNELLA (IT)
RUSSO ELEONORA (IT)
CAFAGGI SERGIO (IT)
BIGNARDI GAETANO (IT)
CIRRINCIONE PAOLA (IT)
Application Number:
PCT/EP2009/006567
Publication Date:
May 27, 2010
Filing Date:
September 10, 2009
Export Citation:
Assignee:
UNIV DEGLI STUDI GENOVA (IT)
CAVIGLIOLI GABRIELE (IT)
PARODI BRUNELLA (IT)
RUSSO ELEONORA (IT)
CAFAGGI SERGIO (IT)
BIGNARDI GAETANO (IT)
CIRRINCIONE PAOLA (IT)
CAVIGLIOLI GABRIELE (IT)
PARODI BRUNELLA (IT)
RUSSO ELEONORA (IT)
CAFAGGI SERGIO (IT)
BIGNARDI GAETANO (IT)
CIRRINCIONE PAOLA (IT)
International Classes:
A61K9/20; A61K9/22; A61K31/55; A61K31/64
Domestic Patent References:
| WO2001095888A1 | 2001-12-20 | |||
| WO2005065685A1 | 2005-07-21 |
Foreign References:
| US5707655A | 1998-01-13 | |||
| FR2880273A1 | 2006-07-07 |
Attorney, Agent or Firm:
BOTTI, Mario et al. (Via Locatelli 5, Milano, IT)
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