Title:
METHOD FOR RECONSTRUCTION OF BLOOD CELL FROM GENE-TRANSFERRED HEMATOPOIETIC CELL
Document Type and Number:
WIPO Patent Application WO/2006/085451
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a method for producing a hematopoietic cell engraftment composition comprising a gene-transferred hematopoietic cell by using a chromosomally unintegrated viral vector, and to provide a method for reconstructing a blood cell from a gene-transferred hematopoietic cell by using a chromosomally unintegrated viral vector. [MEANS FOR SOLVING PROBLEMS] A blood cell capable of expressing a gene introduced therein can be reconstructed by introducing a negative-strand RNA viral vector into a hematopoietic cell and then performing the hematopoietic cell engraftment using the resulting cell. The gene-transferred hematopoietic cell thus produced can be differentiated into a leukocyte, an erythrocyte and a platelet in the body to which the cell has been engrafted. Thus, there is provided a safe gene transfer system for use in the gene therapy by hematopoietic cell engraftment without causing any damage to the chromosomes of a host.
Inventors:
YOSHIDA KUMI (JP)
OKANO SHINJI (JP)
YONEMITSU YOSHIKAZU (JP)
SUEISHI KATSUO (JP)
INOUE MAKOTO (JP)
HASEGAWA MAMORU (JP)
OKANO SHINJI (JP)
YONEMITSU YOSHIKAZU (JP)
SUEISHI KATSUO (JP)
INOUE MAKOTO (JP)
HASEGAWA MAMORU (JP)
Application Number:
PCT/JP2006/301541
Publication Date:
August 17, 2006
Filing Date:
January 31, 2006
Export Citation:
Assignee:
DNAVEC CORP (JP)
YOSHIDA KUMI (JP)
OKANO SHINJI (JP)
YONEMITSU YOSHIKAZU (JP)
SUEISHI KATSUO (JP)
INOUE MAKOTO (JP)
HASEGAWA MAMORU (JP)
YOSHIDA KUMI (JP)
OKANO SHINJI (JP)
YONEMITSU YOSHIKAZU (JP)
SUEISHI KATSUO (JP)
INOUE MAKOTO (JP)
HASEGAWA MAMORU (JP)
International Classes:
A61K48/00; A61K35/12; A61K35/28; A61K35/76; A61P7/00; A61P43/00; C12N15/09
Domestic Patent References:
| WO2004038029A1 | 2004-05-06 | |||
| WO2005097988A1 | 2005-10-20 |
Foreign References:
| JP2004329222A | 2004-11-25 |
Other References:
OKANO S. ET AL.: "Recombinant Sendai virus vectors for activated T lymphocytes", GENE THERAPY, vol. 10, no. 16, 2003, pages 1381 - 1391, XP002973825
JIN C.H. ET AL.: "Recombinant Sendai virus provides a highly efficient gene transfer into human cord blood-derived hematopoietic stem cells", GENE THERAPY, vol. 10, no. 3, 2003, pages 272 - 277, XP002983185
CAVAZZANA-CALVO M. ET AL.: "Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease", SCIENCE, vol. 288, 2000, pages 669 - 672, XP003002263
HACEIN-BEY-ABINA S. ET AL.: "LM02-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1", SCIENCE, vol. 302, 2003, pages 415 - 419, XP002987515
HASEGAWA M.: "Shinki Idenshi Chiryoyo Vector no Kaihatsu", THE CELL, vol. 33, no. 6, 2001, pages 227 - 231, XP002992143
JIN C.H. ET AL.: "Recombinant Sendai virus provides a highly efficient gene transfer into human cord blood-derived hematopoietic stem cells", GENE THERAPY, vol. 10, no. 3, 2003, pages 272 - 277, XP002983185
CAVAZZANA-CALVO M. ET AL.: "Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease", SCIENCE, vol. 288, 2000, pages 669 - 672, XP003002263
HACEIN-BEY-ABINA S. ET AL.: "LM02-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1", SCIENCE, vol. 302, 2003, pages 415 - 419, XP002987515
HASEGAWA M.: "Shinki Idenshi Chiryoyo Vector no Kaihatsu", THE CELL, vol. 33, no. 6, 2001, pages 227 - 231, XP002992143
Attorney, Agent or Firm:
Shimizu, Hatsushi (Oroshi-machi Tsuchiura-shi, Ibaraki 47, JP)
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