Title:
A METHOD FOR THE REDUCTION OF OXYGENATED COMPOUNDS OF RHENIUM OR TECHNETIUM
Document Type and Number:
WIPO Patent Application WO1998014219
Kind Code:
A3
Abstract:
A method for the reduction of oxygenated compounds of rhenium or technetium with a reducing agent, wherein the reduction reaction is carried out in the presence of a macromolecular compound selected from the group consisting of cylic oligosaccharides, crown ethers and cryptands, wherein said macromolecular compound is effective to displace the equilibrium of the reduction reaction toward the formation of the reduced species of said oxygenated compound. The reduction reaction is preferably carried out in the presence of a ligand which can form a complex with rhenium or technetium to provide Tc or Re radiopharmaceuticals. 00000
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Inventors:
DUATTI ADRIANO (IT)
BOLZATI CRISTINA (IT)
UCCELLI LICIA (IT)
FRANCESCHINI RODOLFO (IT)
BOSCHI ALESSANDRA (IT)
BOLZATI CRISTINA (IT)
UCCELLI LICIA (IT)
FRANCESCHINI RODOLFO (IT)
BOSCHI ALESSANDRA (IT)
Application Number:
PCT/EP1997/005448
Publication Date:
June 18, 1998
Filing Date:
October 03, 1997
Export Citation:
Assignee:
SORIN RADIOFARMACI S R L (IT)
DUATTI ADRIANO (IT)
BOLZATI CRISTINA (IT)
UCCELLI LICIA (IT)
FRANCESCHINI RODOLFO (IT)
BOSCHI ALESSANDRA (IT)
DUATTI ADRIANO (IT)
BOLZATI CRISTINA (IT)
UCCELLI LICIA (IT)
FRANCESCHINI RODOLFO (IT)
BOSCHI ALESSANDRA (IT)
International Classes:
A61K51/04; A61K51/00; (IPC1-7): A61K51/04
Domestic Patent References:
| WO1993015765A1 | 1993-08-19 |
Foreign References:
| FR2736834A1 | 1997-01-24 | |||
| EP0311891A1 | 1989-04-19 | |||
| DD265628A1 | 1989-03-08 |
Other References:
HABY ET AL.: "Development of a Stable Single-Vial Formulation for a New Technecium Complex Using Bilayer Lyophilization", PDA J. PHARM. SCI. TECHNOL., vol. 51, no. 2, 1997, pages 68 - 71, XP002060829
HERRMANN ET AL.: "Mehrfachbindungen zwischen Hauptgruppenelementen und Uebergangsmetallen. LXIV. Methyl(trioxo)rhenium: Basenaddukte und Basenreaktionen. Kristallstruktur von [Natrium(benzo-15-krone-5)]-perrhenat", J. ORGANOMET. CHEM., vol. 372, no. 3, 1989, pages 351 - 370, XP002060830
DATABASE WPI Section Ch Week 7839, Derwent World Patents Index; Class E12, AN 78-69510A, XP002060832
DATABASE WPI Section Ch Week 8511, Derwent World Patents Index; Class A97, AN 85-064069, XP002060833
ALBERTO ET AL.: "New Organometallic Technetium Complexes in High and Low Oxidation States", RADIOCHIM. ACTA, vol. 63, 1993, pages 153 - 161, XP002060831
HERRMANN ET AL.: "Mehrfachbindungen zwischen Hauptgruppenelementen und Uebergangsmetallen. LXIV. Methyl(trioxo)rhenium: Basenaddukte und Basenreaktionen. Kristallstruktur von [Natrium(benzo-15-krone-5)]-perrhenat", J. ORGANOMET. CHEM., vol. 372, no. 3, 1989, pages 351 - 370, XP002060830
DATABASE WPI Section Ch Week 7839, Derwent World Patents Index; Class E12, AN 78-69510A, XP002060832
DATABASE WPI Section Ch Week 8511, Derwent World Patents Index; Class A97, AN 85-064069, XP002060833
ALBERTO ET AL.: "New Organometallic Technetium Complexes in High and Low Oxidation States", RADIOCHIM. ACTA, vol. 63, 1993, pages 153 - 161, XP002060831
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