Title:
TECHNETIUM-99M LABELED CHELATOR INCORPORATED CYCLIC PEPTIDES
Document Type and Number:
WIPO Patent Application WO1998014220
Kind Code:
A3
Abstract:
The present invention describes novel radiopharmaceuticals of formula (I): (I) wherein J, K, L, and M, are amino acids or derivatives thereof and R', R1, R2 and n are as defined herein, that are radiolabeled cyclic compounds containing chelators which act as antagonists of the platelet glycoprotein IIb/IIIa complex, methods of using the same as imaging agents for the diagnosis of arterial and venous thrombi, and novel reagents for the preparation of the same and kits comprising the reagents.
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Inventors:
RAJOPADHYE MILIND
SINGH PRAHLAD RAMADHAR
SINGH PRAHLAD RAMADHAR
Application Number:
PCT/US1997/017539
Publication Date:
July 02, 1998
Filing Date:
October 01, 1997
Export Citation:
Assignee:
DU PONT MERCK PHARMA (US)
International Classes:
A61K51/00; A61K51/08; C07K7/56; C07K14/75; (IPC1-7): A61K51/08
Domestic Patent References:
| WO1994022494A1 | 1994-10-13 | |||
| WO1995023811A1 | 1995-09-08 | |||
| WO1994022911A2 | 1994-10-13 | |||
| WO1994022909A1 | 1994-10-13 |
Foreign References:
| EP0500170A2 | 1992-08-26 |
Other References:
PEARSOM ET AL.: "Thrombus Imaging Using Technetium-99m-Labeled High-Potency GPIIb/IIIa Receptor Antagonists. Chemistry and Initial Biological Studies", J. MED. CHEM., vol. 39, no. 7, 1996, pages 1372 - 1382, XP002061485
LISTER-JAMES ET AL.: "Thrombus Imaging with a Technetium-99m-labeled Activated Platelet Receptor Binding Peptide", J. NUCLEAR MEDICINE, vol. 37, no. 5, 1996, pages 775 - 781, XP002061486
LISTER-JAMES ET AL.: "Thrombus Imaging with a Technetium-99m-labeled Activated Platelet Receptor Binding Peptide", J. NUCLEAR MEDICINE, vol. 37, no. 5, 1996, pages 775 - 781, XP002061486
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