METHOD OF REFINING VALSARTAN COMPRISING MORE THAN 10% D-ISOMERS

Title:

METHOD OF REFINING VALSARTAN COMPRISING MORE THAN 10% D-ISOMERS

Document Type and Number:

WIPO Patent Application WO/2015/124102

Kind Code:

A1

Abstract:

The present invention relates to a method of refining valsartan comprising more than 10% D-isomers, the method comprising: adding a solvent to valsartan comprising more than 10% D-isomers and dissolving, adding a certain amount of inorganic base, separating solids out after salification, obtaining the filtrate after filtering, and distilling the filtrate to remove the organic solvent; adjusting the pH of the filtrate, extracting with an organic solvent, concentrating most of the organic solvent, cooling to crystallize, and obtaining the product. The method enables the isomers of the product to be below 0.5%, and produces a yield of more than 40%, being suitable for industrial production.

Inventors:

CHEN YONGBI (CN)
ZHANG WENLING (CN)
WANG PENG (CN)
CHEN JIAN (CN)

Application Number:

PCT/CN2015/073126

Publication Date:

August 27, 2015

Filing Date:

February 15, 2015

Export Citation:

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Assignee:

ZHEJIANG HUAHAI PHARM CO LTD (CN)

International Classes:

C07D257/04

Domestic Patent References:

WO2007069271A2

2007-06-21

Foreign References:

CN103819421A	2014-05-28
CN102617497A	2012-08-01

Other References: