Title:
NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/124101
Kind Code:
A1
Abstract:
The present invention relates to a naphthylamide compound of the structure as represented by formula (I), medicinal salts, prodrugs and hydrates or solvates thereof, and also relates to a method of preparing the compounds, pharmaceutical compositions comprising the compounds and the uses thereof as protein tyrosine kinase inhibitors, particularly as VEGFR-2 inhibitors, in preparing drugs for preventing and treating diseases related to abnormal angiogenesis.
Inventors:
DUAN WENHU (CN)
DING JIAN (CN)
LV YONGCONG (CN)
XIE HUA (CN)
DING JIAN (CN)
LV YONGCONG (CN)
XIE HUA (CN)
Application Number:
PCT/CN2015/073121
Publication Date:
August 27, 2015
Filing Date:
February 15, 2015
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
International Classes:
C07D231/56; C07D261/20; C07D491/048; C07D495/04; A61K31/416; A61K31/422; A61K31/423; A61K31/4355; A61K31/4365; A61K31/4439; A61K31/519; A61P17/06; A61P27/02; A61P29/00; A61P35/00
Domestic Patent References:
| WO2007005668A2 | 2007-01-11 | |||
| WO2000002871A1 | 2000-01-20 | |||
| WO2006039718A2 | 2006-04-13 | |||
| WO2006059234A2 | 2006-06-08 |
Foreign References:
| CN101906076A | 2010-12-08 | |||
| CN102470134A | 2012-05-23 | |||
| CN103288728A | 2013-09-11 | |||
| CN103351336A | 2013-10-16 | |||
| CN103896836A | 2014-07-02 | |||
| CN103923004A | 2014-07-16 | |||
| US5006519A | 1991-04-09 |
Other References:
WEISS, M.M. ET AL.: "Evaluation of a Series of Naphthamides as Potent, Orally Active Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitors", J. MED. CHEM., vol. 51, no. 6, 7 March 2008 (2008-03-07), pages 1668 - 1680, XP055220783, ISSN: 0022-2623
MIDUTURU, C.V. ET AL.: "High-Throughput Kinase Profiling: A More Efficient Approach toward the Discovery of New Kinase Inhibitors", CHEMISTRY & BIOLOGY, vol. 18, no. 7, 29 July 2011 (2011-07-29), pages 868 - 879, XP028248851, ISSN: 1074-5521
LV , YONGCONG ET AL.: "Discovery of a New Series of Naphthamides as Potent VEGFR 2 Kinase Inhibitors", ACS MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 5, 24 February 2014 (2014-02-24), XP055305646, ISSN: 1948-5875
LIU, TING: "Synthesis and Biological Activities of Novel Nitrogen-Containing Heterocyclic Compounds", DOCTORAL DISSERTATIONS OF NANCHANG UNIVERSITY, 31 December 2014 (2014-12-31)
See also references of EP 3112351A4
MIDUTURU, C.V. ET AL.: "High-Throughput Kinase Profiling: A More Efficient Approach toward the Discovery of New Kinase Inhibitors", CHEMISTRY & BIOLOGY, vol. 18, no. 7, 29 July 2011 (2011-07-29), pages 868 - 879, XP028248851, ISSN: 1074-5521
LV , YONGCONG ET AL.: "Discovery of a New Series of Naphthamides as Potent VEGFR 2 Kinase Inhibitors", ACS MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 5, 24 February 2014 (2014-02-24), XP055305646, ISSN: 1948-5875
LIU, TING: "Synthesis and Biological Activities of Novel Nitrogen-Containing Heterocyclic Compounds", DOCTORAL DISSERTATIONS OF NANCHANG UNIVERSITY, 31 December 2014 (2014-12-31)
See also references of EP 3112351A4
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
北京金信知识产权代理有限公司 (CN)
北京金信知识产权代理有限公司 (CN)
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