Title:
METHOD OF REGULATING THE ACTIVITY OF EXPRESSION PRODUCT OF GENE TRANSFERRED INTO LIVING BODY
Document Type and Number:
WIPO Patent Application WO/2002/041922
Kind Code:
A1
Abstract:
The activity of an expression product of a gene which has been transferred into a living body can be regulated by the coexistence of a protein (interference substance) interfering the activity of the expression product. As the interference substance, use is made of a receptor for the expression product, etc. Thus, the excessive activity of an expression product of a gene which has been transferred by gene therapy can be regulated. The interference substance can be administered by expressing its gene in the living body.
Inventors:
MARUYAMA HIROKI (JP)
MIYAZAKI JUN-ICHI (JP)
SUGAWA MAKOTO (JP)
HIGUCHI MASATO (JP)
MIYAZAKI JUN-ICHI (JP)
SUGAWA MAKOTO (JP)
HIGUCHI MASATO (JP)
Application Number:
PCT/JP2001/008575
Publication Date:
May 30, 2002
Filing Date:
September 28, 2001
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
MARUYAMA HIROKI (JP)
MIYAZAKI JUN ICHI (JP)
SUGAWA MAKOTO (JP)
HIGUCHI MASATO (JP)
MARUYAMA HIROKI (JP)
MIYAZAKI JUN ICHI (JP)
SUGAWA MAKOTO (JP)
HIGUCHI MASATO (JP)
International Classes:
A61K48/00; A61P43/00; C07K14/47; C07K14/505; C07K14/71; C12N15/63; C12N15/87; A61K38/00; (IPC1-7): A61K48/00; A61K38/17; A61K39/395; A61K31/711; C12N15/85; A61P43/00
Domestic Patent References:
| WO1997012970A1 | 1997-04-10 | |||
| WO1995009655A1 | 1995-04-13 | |||
| WO1995022617A1 | 1995-08-24 | |||
| WO1996040955A1 | 1996-12-19 | |||
| WO1995024485A2 | 1995-09-14 | |||
| WO1998035028A2 | 1998-08-13 |
Other References:
MARUYAMA HIROKI ET AL.: "Continuous erythropoietin delivery by muscle-targeted gene transfer using in vivo electroporation", HUM. GENE THER., vol. 11, no. 3, 2000, pages 429 - 437, XP002181296
See also references of EP 1344536A4
See also references of EP 1344536A4
Attorney, Agent or Firm:
Shimizu, Hatsushi (Oroshi-machi Tsuchiura-shi, Ibaraki, JP)
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