Title:
METHOD FOR SCREENING FOR CANCER THERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2016/159377
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for screening for a cancer therapeutic agent, which is a molecule targeting drug capable of targeting any one of great many target protein candidates, among from the target protein candidates without requiring the identification of a true target protein.
The present invention can solve the above-mentioned problem by providing a method for screening for a cancer therapeutic agent, said method comprising the steps of: (i) measuring the expression amount of a transposable element in a cancer cell of interest while contacting or non-contacting the transposable element with a test substance; and (ii), when the expression amount of the transposable element under the contacting with a test substance is increased compared with that under the non-contacting with the test substance, selecting the test substance as a cancer therapeutic agent.
Inventors:
YAMADA YASUHIRO (JP)
SEMI KATSUNORI (JP)
YAMAMOTO TAKUYA (JP)
SEMI KATSUNORI (JP)
YAMAMOTO TAKUYA (JP)
Application Number:
PCT/JP2016/060975
Publication Date:
October 06, 2016
Filing Date:
April 01, 2016
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C12Q1/68; C12Q1/02; C12N15/09
Domestic Patent References:
| WO2002046477A2 | 2002-06-13 | |||
| WO2009038756A2 | 2009-03-26 | |||
| WO2010032696A1 | 2010-03-25 |
Other References:
MATSUDA, Y. ET AL.: "Application of iPS cell technology to cancer epigenome study: Uncovering the mechanism of cell status conversion for drug resistance in tumor.", PATHOLOGY INTERNATIONAL, vol. 64, no. 7, July 2014 (2014-07-01), pages 299 - 308, XP055317309, ISSN: 1320-5463
KATSUNORI SEMI ET AL.: "Reprogramming Gijutsu o Mochiita Gan Epigenome Kenkyu", EXPERIMENTAL MEDICINE, vol. 32, no. 19, December 2014 (2014-12-01), pages 3061 - 3065, ISSN: 0288-5514
FORT, A. ET AL.: "Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance.", NATURE GENETICS, vol. 46, no. 6, June 2014 (2014-06-01), pages 558 - 566, XP055290886, ISSN: 1061-4036
KATSUNORI SEMI ET AL.: "Reprogramming Gijutsu o Mochiita Gan Epigenome Kenkyu", EXPERIMENTAL MEDICINE, vol. 32, no. 19, December 2014 (2014-12-01), pages 3061 - 3065, ISSN: 0288-5514
FORT, A. ET AL.: "Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance.", NATURE GENETICS, vol. 46, no. 6, June 2014 (2014-06-01), pages 558 - 566, XP055290886, ISSN: 1061-4036
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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