Title:
METHOD FOR SCREENING THERAPEUTIC AGENT FOR PREMATURE RUPTURE OF MEMBRANES
Document Type and Number:
WIPO Patent Application WO/2015/163531
Kind Code:
A1
Abstract:
The present invention relates to a method for screening a therapeutic agent for premature rupture of membranes and, specifically, to a method for screening a therapeutic agent for premature rupture of membranes by making a wound in the amnion tissue of the isolated placenta, treating the wound with a therapeutic agent candidate and culturing the amnion, and then selecting a therapeutic agent candidate, which is confirmed to promote the healing of the wound, as a therapeutic agent for premature rupture of membranes. The present invention has no ethical problem since the amnion discarded after childbirth is used, and is useful in screening a therapeutic agent for premature rupture of membranes, having excellent validity since the therapeutic agent can be easily screened in an environment similar to the interior of the human body.
Inventors:
HONG SOON CHEOL (KR)
LEE AH YOUNG (KR)
LEE AH YOUNG (KR)
Application Number:
PCT/KR2014/005738
Publication Date:
October 29, 2015
Filing Date:
June 27, 2014
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
G01N33/15; A61K31/19; G01N33/50
Other References:
CZEIZEL ET AL.: "Possible association of folic acid supplementation during pregnancy with reduction of preterm birth: a population-based study", EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, vol. 148, no. 2, 2010, pages 135 - 140, XP026853619
FERGUSON ET AL.: "preterm premature rupture of membranes: nutritional and socioeconomic factors", OBSTETRICS & GYNECOLOGY, vol. 100, no. 6, 2002, pages 1250 - 1256, XP055233337
GOLDENBERG ET AL.: "Biochemical markers for the prediction of reterm birth", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 192, no. 5, 2005, pages S36 - S46, XP004886086
SEGEL ET AL.: "Duration of antibiotic therapy after preterm premature rupture of fetal membranes", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 189, no. 3, 2003, pages 799 - 802, XP055233338
JUNG, WON YEONG: "Epilepsy and pregnancy", 17TH SPRING CONFERENCE OF KOREAN NEUROLOGICAL ASSOCIATION, 1999, pages 29 - 38, ISSN: 1225-7044
FERGUSON ET AL.: "preterm premature rupture of membranes: nutritional and socioeconomic factors", OBSTETRICS & GYNECOLOGY, vol. 100, no. 6, 2002, pages 1250 - 1256, XP055233337
GOLDENBERG ET AL.: "Biochemical markers for the prediction of reterm birth", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 192, no. 5, 2005, pages S36 - S46, XP004886086
SEGEL ET AL.: "Duration of antibiotic therapy after preterm premature rupture of fetal membranes", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 189, no. 3, 2003, pages 799 - 802, XP055233338
JUNG, WON YEONG: "Epilepsy and pregnancy", 17TH SPRING CONFERENCE OF KOREAN NEUROLOGICAL ASSOCIATION, 1999, pages 29 - 38, ISSN: 1225-7044
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
이처영 (KR)
이처영 (KR)
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