Title:
METHOD FOR STABILIZING AND ENHANCING SILK FIBROIN MICROCAPSULE SHELL STRUCTURE USING NANOPARTICLES
Document Type and Number:
WIPO Patent Application WO/2020/200300
Kind Code:
A1
Abstract:
A core-shell microcapsule for stabilizing and enhancing a silk fibroin composite shell using nanoparticles. The shell of the microcapsule is a single-layer composite shell with the thickness of 50-1,000 nm, and comprises silk fibroin and nanoparticles randomly distributed in the single-layer composite shell, and the single-layer composite shell is optionally wrapped by other single-layer or multilayer shells. The other single-layer or multilayer shells each independently comprises silk fibroin and nanoparticles randomly distributed in the other shells, and the silk fibroin and nanoparticles can be the same or different between the shells, including between the single-layer composite shell and the other single-layer or multilayer shells. A method for preparing the core-shell microcapsule comprises: mixing and emulsifying internal phase materials and nanoparticle dispersion solution, and then incubating together with silk fibroin to form a stable silk fibroin/nanoparticle composite shell. The thickness of the composite shell can be controlled according to the type, particle size and density of nanoparticles located on an oil-water interface, and the concentration and molecular weight of silk fibroin.
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Inventors:
WANG XIAOQIN (CN)
Application Number:
PCT/CN2020/083113
Publication Date:
October 08, 2020
Filing Date:
April 03, 2020
Export Citation:
Assignee:
SIMATECH INC (CN)
International Classes:
B01J13/02; A61K9/50; B01J13/20
Foreign References:
| CN1879609A | 2006-12-20 | |||
| CN102600778A | 2012-07-25 | |||
| US20160317993A1 | 2016-11-03 | |||
| CN104151841A | 2014-11-19 | |||
| CN102083306A | 2011-06-01 |
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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