Title:
METHOD OF STABILIZING S-ADENOSYL-L-METHIONINE AND STABILIZED COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2007/083631
Kind Code:
A1
Abstract:
A process for producing an S-adenosyl-L-methionine-containing composition having highly excellent stability. The process comprises adding at least an ascorbic acid compound or a salt thereof to a liquid composition containing S-adenosyl-L-methionine and then either drying the resultant liquid composition or subjecting the resultant liquid composition to crystallization and then separating and drying the precipitate. Also provided are: an S-adenosyl-L-methionine-containing composition obtained by the process; and a molded object obtained from the composition.
Inventors:
TAKANO KENTAROU (JP)
GAYAMA SHINYO (JP)
GAYAMA SHINYO (JP)
Application Number:
PCT/JP2007/050514
Publication Date:
July 26, 2007
Filing Date:
January 16, 2007
Export Citation:
Assignee:
MITSUBISHI GAS CHEMICAL CO (JP)
TAKANO KENTAROU (JP)
GAYAMA SHINYO (JP)
TAKANO KENTAROU (JP)
GAYAMA SHINYO (JP)
International Classes:
A61K31/7076; A61K47/22; A61P1/16; A61P19/02; A61P25/24; C07H19/167
Foreign References:
| JPS57156500A | 1982-09-27 | |||
| JPS5076215A | 1975-06-21 | |||
| JPS59139320A | 1984-08-10 | |||
| JPS61227792A | 1986-10-09 | |||
| JPS5951213A | 1984-03-24 | |||
| JPS5248691A | 1977-04-18 | |||
| JPS6449274A | 1989-02-23 | |||
| JPS6449275A | 1989-02-23 | |||
| JPH03501970A | 1991-05-09 | |||
| JPH0421478A | 1992-01-24 | |||
| JPH0630607A | 1994-02-08 | |||
| EP1091001A1 | 2001-04-11 | |||
| US20020188116A1 | 2002-12-12 |
Other References:
See also references of EP 1982721A4
SCHLENK F.; DEPALMA R. E., J. BIOL. CHEM., vol. 229, 1957, pages 1037 - 1050
SHIOZAKI S. ET AL., AGRIC. BIOL. CEM., vol. 53, 1989, pages 3269 - 3274
SCHLENK F.; DEPALMA R. E., J. BIOL. CHEM., vol. 229, 1957, pages 1051 - 1057
KUSAKABE H.; KUNINAKA A.; YOSHINO H, AGRIC. BIOL. CEM., vol. 38, 1974, pages 1669 - 1672
MUDD SH.; CANTONI GL. ET AL., J. BIOL. CHEM., vol. 231, 1958, pages 481 - 492
MARKHAM G. D. ET AL., J. BIOL. CHEM., vol. 225, 1980, pages 9082 - 9092
MARKHAM D.J; DEPARISIS J., J. BIOL. CHEM., vol. 259, 1984, pages 14505 - 14507
SHIOZAKI S. ET AL., J. BIOTECHNOLOGY., vol. 4, 1986, pages 345 - 354
THOMAS D.; SURDIN-KERJAN Y., J. BIOL. CHEM., vol. 262, 1987, pages 16704 - 16709
THOMAS D.; CHEREST H. ET AL., MOL. CELL. BIOL., vol. 8, 1988, pages 5132 - 5139
JOSE R. MATOR; FRANK M. RAUSHEL; CHI-HUEY WONG., BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, vol. 9, 1987, pages 39 - 52
JEONGHO PARK ET AL., BIOORGANIC & MEDICAL CHEMISTRY, vol. 4, no. 12, 1996, pages 2179 - 2185
SCHLENK F.; DEPALMA R. E., J. BIOL. CHEM., vol. 229, 1957, pages 1037 - 1050
SHIOZAKI S. ET AL., AGRIC. BIOL. CEM., vol. 53, 1989, pages 3269 - 3274
SCHLENK F.; DEPALMA R. E., J. BIOL. CHEM., vol. 229, 1957, pages 1051 - 1057
KUSAKABE H.; KUNINAKA A.; YOSHINO H, AGRIC. BIOL. CEM., vol. 38, 1974, pages 1669 - 1672
MUDD SH.; CANTONI GL. ET AL., J. BIOL. CHEM., vol. 231, 1958, pages 481 - 492
MARKHAM G. D. ET AL., J. BIOL. CHEM., vol. 225, 1980, pages 9082 - 9092
MARKHAM D.J; DEPARISIS J., J. BIOL. CHEM., vol. 259, 1984, pages 14505 - 14507
SHIOZAKI S. ET AL., J. BIOTECHNOLOGY., vol. 4, 1986, pages 345 - 354
THOMAS D.; SURDIN-KERJAN Y., J. BIOL. CHEM., vol. 262, 1987, pages 16704 - 16709
THOMAS D.; CHEREST H. ET AL., MOL. CELL. BIOL., vol. 8, 1988, pages 5132 - 5139
JOSE R. MATOR; FRANK M. RAUSHEL; CHI-HUEY WONG., BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, vol. 9, 1987, pages 39 - 52
JEONGHO PARK ET AL., BIOORGANIC & MEDICAL CHEMISTRY, vol. 4, no. 12, 1996, pages 2179 - 2185
Attorney, Agent or Firm:
OHTANI, Tamotsu (Bridgestone Toranomon Bldg. 6F. 25-2, Toranomon 3-chome,, Minato-k, Tokyo 01, JP)
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