Title:
METHOD OF STABILIZING THROMBIN AND COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/146043
Kind Code:
A1
Abstract:
A method of stabilizing thrombin in a thrombin solution is provided. The method comprises heating the thrombin solution at a temperature of 35-85℃ for 1 to 20 seconds, and quenching the heating. Also provided is a stabilized thrombin composition. The stabilized thrombin composition is characterized in that it is prepared by heating a thrombin solution at a temperature of 35-85℃ for 1 to 20 seconds, and quenching the heating. The thrombin solution may be further lyophilized to obtain a stabilized thrombin composition in lyophilized form.
Inventors:
SUN CHUNG CHIN (CN)
SU CHENG-YAO (CN)
SU CHENG-YAO (CN)
Application Number:
PCT/CN2016/076268
Publication Date:
September 22, 2016
Filing Date:
March 14, 2016
Export Citation:
Assignee:
SUN CHUNG CHIN (CN)
International Classes:
A61K38/48
Domestic Patent References:
| WO2008157304A2 | 2008-12-24 | |||
| WO2014087394A1 | 2014-06-12 |
Foreign References:
| CN101757616A | 2010-06-30 | |||
| CN104328101A | 2015-02-04 |
Other References:
See also references of EP 3268030A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (Tower E3 The Towers, Oriental Plaza,No.1 East Chang An Avenue, Dongcheng District, Beijing 8, CN)
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