Title:
METHOD OF SYNTHESIZING [18F]SFB USING MICROSYNTHESIS TECHNIQUE
Document Type and Number:
WIPO Patent Application WO/2010/101118
Kind Code:
A1
Abstract:
Use is made of a microreactor which comprises a substrate having, formed therein, one passage having a cross section with a width and a depth of 1 mm or less each, the passage having a starting-material injection opening and a first reagent injection opening that are connected to one end of the passage, further having a second reagent injection opening connected to a position separated from the end, and furthermore having a third reagent injection opening connected to a position separated from the second reagent injection opening toward the other end of the passage, the other end of the passage being connected to a liquid takeout opening. The passage is used as a reaction channel while passing a reaction solution from the end of the passage toward the other end, and the reaction solution is made to consecutively undergo a three-stage reaction, without being taken out anywhere along the passage, to synthesize [18F]SFB.
Inventors:
NAKANISHI HIROAKI (JP)
SAIKI HIDEKAZU (JP)
SAJI HIDEO (JP)
KIMURA HIROYUKI (JP)
KAWASHIMA HIDEKAZU (JP)
TOMATSU KENJI (JP)
KUGE YUJI (JP)
SAIKI HIDEKAZU (JP)
SAJI HIDEO (JP)
KIMURA HIROYUKI (JP)
KAWASHIMA HIDEKAZU (JP)
TOMATSU KENJI (JP)
KUGE YUJI (JP)
Application Number:
PCT/JP2010/053252
Publication Date:
September 10, 2010
Filing Date:
March 01, 2010
Export Citation:
Assignee:
SHIMADZU CORP (JP)
UNIV KYOTO (JP)
NAKANISHI HIROAKI (JP)
SAIKI HIDEKAZU (JP)
SAJI HIDEO (JP)
KIMURA HIROYUKI (JP)
KAWASHIMA HIDEKAZU (JP)
TOMATSU KENJI (JP)
KUGE YUJI (JP)
UNIV KYOTO (JP)
NAKANISHI HIROAKI (JP)
SAIKI HIDEKAZU (JP)
SAJI HIDEO (JP)
KIMURA HIROYUKI (JP)
KAWASHIMA HIDEKAZU (JP)
TOMATSU KENJI (JP)
KUGE YUJI (JP)
International Classes:
C07D207/404; A61K51/00; C07B59/00; C07B61/00
Foreign References:
| JP2008037767A | 2008-02-21 | |||
| JP2004313867A | 2004-11-11 |
Other References:
TANG, G. ET AL.: "Facile synthesis of N-succinimidyl 4- [18F] fluorobenzoate ([18F] SFB) for protein labeling", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 51, 2008, pages 68 - 71
MILLER, P.W. ET AL.: "Radiolabelling with short-lived PET (positron emission tomography) isotopes using microfluidic reactors", J CHEM TECHNOL BIOTECHNOL, vol. 84, no. 3, 30 October 2008 (2008-10-30), pages 309 - 315
BANNWARTH, W. ET AL.: "Formation of carboxamides with N, N, N', N'-tetramethyl (succinimido) uronium tetrafluoroborate in aqueous/ organic solvent systems", TETRAHEDRON LETTERS, vol. 32, no. 9, 1991, pages 1157 - 1160
"Abstracts of Annual Meeting of Pharmaceutic", vol. 129, 5 March 2009, article KENJI TOMATSU ET AL.: "Microreactor o Mochiita N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) no Jinsoku Gosei Ho no Kaihatsu", pages: 86
G. TANG ET AL., J. LABEL. COMPD. RADIOPHARM., vol. 51, 2008, pages 68 - 71
F. WUST ET AL., APPL. RADIAT ISOT, vol. 59, 2003, pages 43 - 48
HJ. WESTER ET AL., NUCL. MED. BIOL., vol. 23, 1996, pages 365 - 372
W. BANNWARTH ET AL., TETRAHEDRON LETTERS, vol. 32, 1991, pages 1157 - 1160
See also references of EP 2404903A4
MILLER, P.W. ET AL.: "Radiolabelling with short-lived PET (positron emission tomography) isotopes using microfluidic reactors", J CHEM TECHNOL BIOTECHNOL, vol. 84, no. 3, 30 October 2008 (2008-10-30), pages 309 - 315
BANNWARTH, W. ET AL.: "Formation of carboxamides with N, N, N', N'-tetramethyl (succinimido) uronium tetrafluoroborate in aqueous/ organic solvent systems", TETRAHEDRON LETTERS, vol. 32, no. 9, 1991, pages 1157 - 1160
"Abstracts of Annual Meeting of Pharmaceutic", vol. 129, 5 March 2009, article KENJI TOMATSU ET AL.: "Microreactor o Mochiita N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) no Jinsoku Gosei Ho no Kaihatsu", pages: 86
G. TANG ET AL., J. LABEL. COMPD. RADIOPHARM., vol. 51, 2008, pages 68 - 71
F. WUST ET AL., APPL. RADIAT ISOT, vol. 59, 2003, pages 43 - 48
HJ. WESTER ET AL., NUCL. MED. BIOL., vol. 23, 1996, pages 365 - 372
W. BANNWARTH ET AL., TETRAHEDRON LETTERS, vol. 32, 1991, pages 1157 - 1160
See also references of EP 2404903A4
Attorney, Agent or Firm:
NOGUCHI SHIGEO (JP)
Shigeo Noguchi (JP)
Shigeo Noguchi (JP)
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