Title:
CELL MASS DERIVED FROM CANCER TISSUE AND PROCESS FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2010/101119
Kind Code:
A1
Abstract:
Disclosed is a novel cell mass derived from a cancer tissue, which can reflect the in vivo behavior of a cancer cell correctly. Also disclosed is a process for preparing the cell mass. Specifically disclosed is a cell mass derived from a cancer tissue, which is an isolated product that is isolated from a cancer tissue obtained from an individual as a mass containing at least three cancer cells or a culture of the isolated product and which can retain a proliferation ability in vitro. The cell mass derived from a cancer tissue is produced by, for example, a preparation process comprising the steps of: treating a pulverized product of a cancer tissue removed from a living body with an enzyme; and selecting and collecting a mass containing at least three cancer cells among from an enzymatic treatment product.
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Inventors:
INOUE MASAHIRO (JP)
OHUE MASAYUKI (JP)
OHUE MASAYUKI (JP)
Application Number:
PCT/JP2010/053253
Publication Date:
September 10, 2010
Filing Date:
March 01, 2010
Export Citation:
Assignee:
REI MEDICAL CO LTD (JP)
OSAKA PREFECTURAL HOSPITAL ORG (JP)
INOUE MASAHIRO (JP)
OHUE MASAYUKI (JP)
OSAKA PREFECTURAL HOSPITAL ORG (JP)
INOUE MASAHIRO (JP)
OHUE MASAYUKI (JP)
International Classes:
C12N5/09
Domestic Patent References:
| WO2005123902A1 | 2005-12-29 |
Other References:
MASAYUKI FUKUDA: "Hito Nyugan Saibo o Mochiita Collagen Gell Baiyo Ho no Kento", THE JOURNAL OF THE KURUME MEDICAL ASSOCIATION, vol. 57, no. 7/8, 1994, pages 760 - 768, XP008163244
NAGLE R B ET AL.: "Adhesion molecules, extracellular matrix, and proteases in prostate carcinoma.", J CELL BIOCHEM, vol. 56, no. 19, 1994, pages 232 - 237, XP000565798
SHUN'ICHIRO KUBOTA ET AL.: "Laminin Peptide to Gan Ten'i", EXPERIMENTAL MEDICINE, vol. 8, no. 1, 1990, pages 55 - 57, XP008163246
SHIN'YA KOJIMA ET AL.: "Koku Hempei Jyohi Gan no Shitsujun to Ten'i no Kijo ni Kansuru Jikkenteki Kenkyu Dai 6 Po: in vitro Model ni Okeru Kitei Maku Seibun to Kishitsu Bunkai Koso no Sansei ni Kansuru Kento", JOURNAL OF THE JAPANESE STOMATOLOGICAL SOCIETY, vol. 43, no. 3, 1994, pages 355 - 362, XP008163248
See also references of EP 2412803A4
TAKAMURA Y ET AL.: "Prediction of chemotherapeutic response by collagen gel droplet embedded culture-drug sensitivity test in human breast cancers", INT. J. CANCER, vol. 98, 2002, pages 450 - 455
VERMEULEN L ET AL.: "Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity", PNAS, vol. 105, no. 36, 2008, pages 13427 - 13432
RICCI-VITIANI L ET AL.: "Identification and expansion of human colon-cancer-initiating cells", NATURE, vol. 445, 2007, pages 111 - 115
TODARO M ET AL.: "Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4", CELL STEM CELL, vol. 1, 2007, pages 389 - 402
SHMELKOV S V ET AL.: "CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 118, 2008, pages 2111 - 2120
KELLER ET AL., CURR. OPIN. CELL BIOL., vol. 7, 1995, pages 862 - 869
WATANABE ET AL., NATURE NEUROSCIENCE, vol. 8, 2005, pages 288 - 296
NAGLE R B ET AL.: "Adhesion molecules, extracellular matrix, and proteases in prostate carcinoma.", J CELL BIOCHEM, vol. 56, no. 19, 1994, pages 232 - 237, XP000565798
SHUN'ICHIRO KUBOTA ET AL.: "Laminin Peptide to Gan Ten'i", EXPERIMENTAL MEDICINE, vol. 8, no. 1, 1990, pages 55 - 57, XP008163246
SHIN'YA KOJIMA ET AL.: "Koku Hempei Jyohi Gan no Shitsujun to Ten'i no Kijo ni Kansuru Jikkenteki Kenkyu Dai 6 Po: in vitro Model ni Okeru Kitei Maku Seibun to Kishitsu Bunkai Koso no Sansei ni Kansuru Kento", JOURNAL OF THE JAPANESE STOMATOLOGICAL SOCIETY, vol. 43, no. 3, 1994, pages 355 - 362, XP008163248
See also references of EP 2412803A4
TAKAMURA Y ET AL.: "Prediction of chemotherapeutic response by collagen gel droplet embedded culture-drug sensitivity test in human breast cancers", INT. J. CANCER, vol. 98, 2002, pages 450 - 455
VERMEULEN L ET AL.: "Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity", PNAS, vol. 105, no. 36, 2008, pages 13427 - 13432
RICCI-VITIANI L ET AL.: "Identification and expansion of human colon-cancer-initiating cells", NATURE, vol. 445, 2007, pages 111 - 115
TODARO M ET AL.: "Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4", CELL STEM CELL, vol. 1, 2007, pages 389 - 402
SHMELKOV S V ET AL.: "CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 118, 2008, pages 2111 - 2120
KELLER ET AL., CURR. OPIN. CELL BIOL., vol. 7, 1995, pages 862 - 869
WATANABE ET AL., NATURE NEUROSCIENCE, vol. 8, 2005, pages 288 - 296
Attorney, Agent or Firm:
UNIUS PATENT ATTORNEYS OFFICE (JP)
Patent business corporation ユニアス international patent firm (JP)
Patent business corporation ユニアス international patent firm (JP)
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