Title:
METHOD FOR SYNTHESIZING BILIRUBIN
Document Type and Number:
WIPO Patent Application WO/2023/018214
Kind Code:
A1
Abstract:
The present invention relates to a method for synthesizing bilirubin. The present invention relates to a method for chemically synthesizing bilirubin and PEGylated bilirubin, which are helpfully used for a medicinal product or the like, for the first time, by comprising a step of preparing a compound represented by chemical formula 2 through the dimerization of a compound represented by chemical formula 1 or the coupling of a compound represented by chemical formula 3 and a compound represented by chemical formula 4.
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Inventors:
KIM MYUNG LIP (KR)
MA SANG HO (KR)
PARK KI SOO (KR)
KIM JIN BEOM (KR)
JUN HEE GOO (KR)
KIM DA EUN (KR)
MA SANG HO (KR)
PARK KI SOO (KR)
KIM JIN BEOM (KR)
JUN HEE GOO (KR)
KIM DA EUN (KR)
Application Number:
PCT/KR2022/011910
Publication Date:
February 16, 2023
Filing Date:
August 10, 2022
Export Citation:
Assignee:
BILIX CO LTD (KR)
International Classes:
C07D403/14; A61K31/409
Other References:
STEFAN E. BOIADJIEV ; DAVID A. LIGHTNER: "13C-labeled bilirubin: synthesis of 31(32),171(172)-di-[13C]-mesobilirubin-XIIIα", MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY ; AN INTERNATIONAL JOURNAL OF CHEMISTRY, SPRINGER-VERLAG, AU, vol. 140, no. 1, 25 September 2008 (2008-09-25), AU , pages 111 - 119, XP019723031, ISSN: 1434-4475
BROWER, J.O. LIGHTNER, D.A. MCDONAGH, A.F.: "Aromatic congeners of bilirubin: synthesis, stereochemistry, glucuronidation and hepatic transport", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 57, no. 37, 10 September 2001 (2001-09-10), AMSTERDAM, NL , pages 7813 - 7827, XP004304424, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)00773-6
SANJEEV K. DEY ; DAVID A. LIGHTNER: "Lipid and water-soluble bilirubins", MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY ; AN INTERNATIONAL JOURNAL OF CHEMISTRY, SPRINGER-VERLAG, AU, vol. 141, no. 1, 19 January 2010 (2010-01-19), AU , pages 101 - 109, XP019783265, ISSN: 1434-4475, DOI: 10.1007/s00706-009-0232-5
RIBO, J.M. ; SALGADO, A. ; SESE, M.L. ; TRULL, F.R. ; VALLES, M.A.: "Reactivity of pyrrole pigments", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 43, no. 22, 1 January 1987 (1987-01-01), AMSTERDAM, NL , pages 5321 - 5328, XP026648598, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)87709-7
NOGALES DANIEL F., DAVID A. LIGHTNER: "Synthesis of a [13CO2H]‐labelled bilirubin", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 34, no. 5, 31 May 1994 (1994-05-31), pages 453 - 462, XP093034531, DOI: 10.1002/jlcr.2580340508
BROWER, J.O. LIGHTNER, D.A. MCDONAGH, A.F.: "Aromatic congeners of bilirubin: synthesis, stereochemistry, glucuronidation and hepatic transport", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 57, no. 37, 10 September 2001 (2001-09-10), AMSTERDAM, NL , pages 7813 - 7827, XP004304424, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)00773-6
SANJEEV K. DEY ; DAVID A. LIGHTNER: "Lipid and water-soluble bilirubins", MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY ; AN INTERNATIONAL JOURNAL OF CHEMISTRY, SPRINGER-VERLAG, AU, vol. 141, no. 1, 19 January 2010 (2010-01-19), AU , pages 101 - 109, XP019783265, ISSN: 1434-4475, DOI: 10.1007/s00706-009-0232-5
RIBO, J.M. ; SALGADO, A. ; SESE, M.L. ; TRULL, F.R. ; VALLES, M.A.: "Reactivity of pyrrole pigments", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 43, no. 22, 1 January 1987 (1987-01-01), AMSTERDAM, NL , pages 5321 - 5328, XP026648598, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)87709-7
NOGALES DANIEL F., DAVID A. LIGHTNER: "Synthesis of a [13CO2H]‐labelled bilirubin", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 34, no. 5, 31 May 1994 (1994-05-31), pages 453 - 462, XP093034531, DOI: 10.1002/jlcr.2580340508
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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