Title:
METHOD FOR SYNTHESIZING BILIRUBIN
Document Type and Number:
WIPO Patent Application WO/2023/018215
Kind Code:
A1
Abstract:
The present invention relates to a method for synthesizing bilirubin. The present invention relates to a first method for chemically synthesizing bilirubin and PEGylated bilirubin, which are usefully used in a medicinal product or the like, by comprising a step of preparing a compound represented by chemical formula 2 through the dimerization of a compound represented by chemical formula 1 or the coupling of a compound represented by chemical formula 3 and a compound represented by chemical formula 4.
Inventors:
KIM MYUNG LIP (KR)
MA SANG HO (KR)
PARK KI SOO (KR)
KIM JIN BEOM (KR)
JUN HEE GOO (KR)
KIM DA EUN (KR)
MA SANG HO (KR)
PARK KI SOO (KR)
KIM JIN BEOM (KR)
JUN HEE GOO (KR)
KIM DA EUN (KR)
Application Number:
PCT/KR2022/011913
Publication Date:
February 16, 2023
Filing Date:
August 10, 2022
Export Citation:
Assignee:
BILIX CO LTD (KR)
International Classes:
C07D403/14; A61K31/409; C07D207/38
Other References:
BROWER, J.O. LIGHTNER, D.A. MCDONAGH, A.F.: "Synthesis of a New Lipophilic Bilirubin. Conformation, Transhepatic Transport and Glucuronidation", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 56, no. 40, 29 September 2000 (2000-09-29), AMSTERDAM, NL , pages 7869 - 7883, XP004217288, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(00)00710-9
BROWER, J.O. LIGHTNER, D.A. MCDONAGH, A.F.: "Aromatic congeners of bilirubin: synthesis, stereochemistry, glucuronidation and hepatic transport", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 57, no. 37, 10 September 2001 (2001-09-10), AMSTERDAM, NL , pages 7813 - 7827, XP004304424, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)00773-6
SANJEEV K. DEY ; DAVID A. LIGHTNER: "Lipid and water-soluble bilirubins", MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY ; AN INTERNATIONAL JOURNAL OF CHEMISTRY, SPRINGER-VERLAG, AU, vol. 141, no. 1, 19 January 2010 (2010-01-19), AU , pages 101 - 109, XP019783265, ISSN: 1434-4475, DOI: 10.1007/s00706-009-0232-5
SABIDO PORTIA MAHAL G., LIGHTNER DAVID A.: "Synthesis and properties of mesobilirubins XIIγ and XIIIγ and their mesobiliverdins", MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY, SPRINGER VIENNA, VIENNA, vol. 145, no. 5, 1 May 2014 (2014-05-01), Vienna, pages 775 - 789, XP093035015, ISSN: 0026-9247, DOI: 10.1007/s00706-014-1160-6
DEY SANJEEV K., LIGHTNER DAVID A.: "Toward an Amphiphilic Bilirubin: The Crystal Structure of a Bilirubin E -Isomer", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 73, no. 7, 1 April 2008 (2008-04-01), pages 2704 - 2714, XP093035017, ISSN: 0022-3263, DOI: 10.1021/jo702593x
BROWER, J.O. LIGHTNER, D.A. MCDONAGH, A.F.: "Aromatic congeners of bilirubin: synthesis, stereochemistry, glucuronidation and hepatic transport", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 57, no. 37, 10 September 2001 (2001-09-10), AMSTERDAM, NL , pages 7813 - 7827, XP004304424, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)00773-6
SANJEEV K. DEY ; DAVID A. LIGHTNER: "Lipid and water-soluble bilirubins", MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY ; AN INTERNATIONAL JOURNAL OF CHEMISTRY, SPRINGER-VERLAG, AU, vol. 141, no. 1, 19 January 2010 (2010-01-19), AU , pages 101 - 109, XP019783265, ISSN: 1434-4475, DOI: 10.1007/s00706-009-0232-5
SABIDO PORTIA MAHAL G., LIGHTNER DAVID A.: "Synthesis and properties of mesobilirubins XIIγ and XIIIγ and their mesobiliverdins", MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY, SPRINGER VIENNA, VIENNA, vol. 145, no. 5, 1 May 2014 (2014-05-01), Vienna, pages 775 - 789, XP093035015, ISSN: 0026-9247, DOI: 10.1007/s00706-014-1160-6
DEY SANJEEV K., LIGHTNER DAVID A.: "Toward an Amphiphilic Bilirubin: The Crystal Structure of a Bilirubin E -Isomer", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 73, no. 7, 1 April 2008 (2008-04-01), pages 2704 - 2714, XP093035017, ISSN: 0022-3263, DOI: 10.1021/jo702593x
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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