Title:
METHOD FOR SYNTHESIZING CHIRAL DIAMINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/168987
Kind Code:
A1
Abstract:
Provided is a method for synthesizing a chiral diamine compound. The synthesizing method comprises: converting a substrate represented by formula I into a formula I chiral diamine compound by using transaminases, wherein n=1-10, an R group represents an alkyl group, a cycloalkyl group, a heteroatom-containing alkyl group, a heteroatom-containing cycloalkyl group, a heteroatom-containing aryl group, an amide compound residue, or an ether compound residue, and a hetero atom is at least one from among O, S and N; R1 and R2 are the same or not the same, the R1 and R2 are respectively and independently hydrogen, C1-C3 alkyl groups, or amino protecting groups; and the transaminases are derived from a plurality of strains, Said transaminases all have a relatively high reaction selectivity and activity on various substrates represented by formula 1. By catalyzing and synthesizing a chiral diamine compound by using said biological enzyme, not only is the substrate scope wider, but the route also short and product yield high, thus greatly reducing production costs and reducing the production of an organic solvent and the three wastes.
Inventors:
HONG HAO (US)
JAMES GAGE (US)
XIAO YI (CN)
ZHANG NA (CN)
LI XIANG (CN)
JIANG XIANGJUN (CN)
ZHAO TONG (CN)
JAMES GAGE (US)
XIAO YI (CN)
ZHANG NA (CN)
LI XIANG (CN)
JIANG XIANGJUN (CN)
ZHAO TONG (CN)
Application Number:
PCT/CN2020/082594
Publication Date:
September 02, 2021
Filing Date:
March 31, 2020
Export Citation:
Assignee:
ASYMCHEM LAB TIANJIN CO LTD (CN)
International Classes:
C12P13/00; C12N9/10; C12P17/04; C12P17/12
Foreign References:
| CN110616236A | 2019-12-27 | |||
| CN110592042A | 2019-12-20 | |||
| CN105367427A | 2016-03-02 | |||
| CN105753752A | 2016-07-13 |
Other References:
WANG LU: "Efficient Expression of Transaminase ATA117in Escherichia Coli for the Production of Sitagliptin", CHINESE MASTER’S THESES FULL-TEXT DATABASE, ENGINEERING SCIENCE AND TECHNOLOGY I, 15 June 2014 (2014-06-15), XP055841860
ANGEW.CHEM. INT. ED., vol. 37, 1998, pages 2580
CHEM.REV., vol. 111, 2011, pages 6947
ANGEW.CHEM. INT. ED., vol. 37, 1998, pages 2580
CHEM.REV., vol. 111, 2011, pages 6947
Attorney, Agent or Firm:
KANGXIN PARTNERS, P.C. (CN)
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