Title:
SYNTHESIS METHOD FOR FLUORINE-CONTAINING CHIRAL AMINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/168988
Kind Code:
A1
Abstract:
The present invention provides a synthesis method for a fluorine-containing chiral amine compound. The synthesis method comprises: reacting an amino donor with a fluorine-containing dihydroxy ketal compound under the catalysis of transaminase to generate a fluorine-containing chiral amine compound, wherein the transaminase is derived from a plurality of strains. The transaminase of the present application has substrate specificity on the fluorine-containing dihydroxy ketal compound, can effectively catalyze the substrate to be converted into the fluorine-containing chiral amine compound, has catalytic activity on multiple fluorine-containing dihydroxy ketal compounds, and is relatively high in reaction selectivity and activity. The bio-enzyme catalytic synthesis method is not only short in route, but also high in product yield, the production cost is greatly reduced, and the production of organic solvents and three wastes is reduced.
Inventors:
HONG HAO (US)
JAMES GAGE (US)
XIAO YI (CN)
ZHANG NA (CN)
LI XIANG (CN)
JIANG XIANGJUN (CN)
LV SHUNXING (CN)
JAMES GAGE (US)
XIAO YI (CN)
ZHANG NA (CN)
LI XIANG (CN)
JIANG XIANGJUN (CN)
LV SHUNXING (CN)
Application Number:
PCT/CN2020/082595
Publication Date:
September 02, 2021
Filing Date:
March 31, 2020
Export Citation:
Assignee:
ASYMCHEM LAB TIANJIN CO LTD (CN)
International Classes:
C07C319/20; C07C211/15; C07C211/29; C07C211/35; C07C213/02; C07C217/26; C07C231/12; C07C233/78; C07C323/25; C07D209/34; C07D213/38; C07D235/14; C07D307/33; C12N9/10; C12P13/00; C12P17/12
Foreign References:
| CN110592042A | 2019-12-20 | |||
| CN108048419A | 2018-05-18 | |||
| EP3415630A1 | 2018-12-19 |
Other References:
See also references of EP 4116289A4
Attorney, Agent or Firm:
KANGXIN PARTNERS, P.C. (CN)
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