Title:
METHOD FOR SYNTHESIZING ZIRCONIUM COMPLEX
Document Type and Number:
WIPO Patent Application WO/2021/019983
Kind Code:
A1
Abstract:
The purpose of the present invention is to react radioactive zirconium at a high reaction rate to synthesize a zirconium complex even using low-concentration DOTA or NOTA. A mixed solution, obtained by finally mixing zirconium dissolved in an acidic solution into a solution obtained by mixing a solution that includes 1-95 vol% (inclusive) of an organic substance having a dipole moment of 3.0D or higher and a compound that includes a chelating agent represented by 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), etc., is heated to a prescribed temperature of 35°C or higher to synthesize a zirconium complex. The acidic solution is hydrochloric acid, and the organic substance is at least one selected from the group consisting of dimethyl sulfoxide (DMSO), N,N-dimethylformamide (DMF), N-methylformamide (NMF), N-methylpyrrolidone (NMP), and urea.
Inventors:
IMURA RYOTA (JP)
Application Number:
PCT/JP2020/025031
Publication Date:
February 04, 2021
Filing Date:
June 25, 2020
Export Citation:
Assignee:
JFE ENG CORP (JP)
International Classes:
C07D255/02; A61K51/04; C07D257/02; C07D403/06; C07D403/12; C07D487/04; C07F7/00; C22B3/26; C22B34/14
Domestic Patent References:
| WO2019125982A1 | 2019-06-27 | |||
| WO2017161356A1 | 2017-09-21 |
Foreign References:
| US20140147381A1 | 2014-05-29 | |||
| JP2018123372A | 2018-08-09 | |||
| JPH0365806B2 | 1991-10-15 |
Other References:
GRAVES STEPHEN A.; KUTYREFF CHRISTOPHER; BARRETT KENDALL E.; HERNANDEZ REINIER; ELLISON PAUL A.; HAPPEL STEFFEN; ALUICIO-SARDUY ED: "Evaluation of a chloride-based89Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin", NUCL. MED. BIOL., ELSEVIER, NY., US, vol. 64, 18 June 2018 (2018-06-18), US, pages 1 - 7, XP085493278, ISSN: 0969-8051, DOI: 10.1016/j.nucmedbio.2018.06.003
TAHA MOHAMED, KHOIROH IANATUL, LEE MING-JER: "Phase Behavior and Molecular Dynamics Simulation Studies of New Aqueous Two-Phase Separation Systems Induced by HEPES Buffer", JOURNAL OF PHYSICAL CHEMISTRY PART B, AMERICAN CHEMICAL SOCIETY, US, vol. 117, no. 2, 17 January 2013 (2013-01-17), US, pages 563 - 582, XP055789501, ISSN: 1520-6106, DOI: 10.1021/jp305516g
PANDYA DARPAN N., BHATT NIKUNJ, YUAN HONG, DAY CYNTHIA S., EHRMANN BRANDIE M., WRIGHT MARCUS, BIERBACH ULRICH, WADAS THADDEUS J.: "Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 8, no. 3, 1 January 2017 (2017-01-01), United Kingdom, pages 2309 - 2314, XP055789504, ISSN: 2041-6520, DOI: 10.1039/C6SC04128K
"Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development", CHEM. SCI., vol. 8, 2017, pages 2309 - 2314
"Evaluation of a chloride-based 89Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin", NUCL. BIO. AND MED., vol. 64, 2018, pages 1 - 7
See also references of EP 4006015A4
TAHA MOHAMED, KHOIROH IANATUL, LEE MING-JER: "Phase Behavior and Molecular Dynamics Simulation Studies of New Aqueous Two-Phase Separation Systems Induced by HEPES Buffer", JOURNAL OF PHYSICAL CHEMISTRY PART B, AMERICAN CHEMICAL SOCIETY, US, vol. 117, no. 2, 17 January 2013 (2013-01-17), US, pages 563 - 582, XP055789501, ISSN: 1520-6106, DOI: 10.1021/jp305516g
PANDYA DARPAN N., BHATT NIKUNJ, YUAN HONG, DAY CYNTHIA S., EHRMANN BRANDIE M., WRIGHT MARCUS, BIERBACH ULRICH, WADAS THADDEUS J.: "Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 8, no. 3, 1 January 2017 (2017-01-01), United Kingdom, pages 2309 - 2314, XP055789504, ISSN: 2041-6520, DOI: 10.1039/C6SC04128K
"Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development", CHEM. SCI., vol. 8, 2017, pages 2309 - 2314
"Evaluation of a chloride-based 89Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin", NUCL. BIO. AND MED., vol. 64, 2018, pages 1 - 7
See also references of EP 4006015A4
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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