Title:
METHOD AND SYSTEM FOR EXAMINING ATRIAL ARRHYTHMIAS
Document Type and Number:
WIPO Patent Application WO/2020/158260
Kind Code:
A1
Abstract:
The problem to be solved by the present invention is to provide a method for examining atrial arrhythmias for diagnosing atrial arrhythmias or predicting the onset thereof and an examination system therefor. The method for examining atrial arrhythmias according to the present invention, which is for diagnosing atrial arrhythmias or predicting the onset thereof, is characterized by comprising a step for quantitating at least one microRNA (hereinafter referred to as "miRNA") which is selected from four miRNAs including miR-99a-5p, miR-192-5p, miR-214-3p and miR-342-5p, among miRNAs contained in a non-cellular biological liquid obtained from a subject, or at least one miRNA which has a base sequence wherein at least six bases are the same as the bases in the sequence consisting of seven bases at the 2nd to 8th positions in at least one of the aforesaid four miRNAs or which possesses the same target gene as at least one of the four miRNAs.
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Inventors:
SASANO TETSUO (JP)
FURUKAWA TETSUSHI (JP)
FURUKAWA TETSUSHI (JP)
Application Number:
PCT/JP2019/050622
Publication Date:
August 06, 2020
Filing Date:
December 24, 2019
Export Citation:
Assignee:
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
KONICA MINOLTA INC (JP)
KONICA MINOLTA INC (JP)
International Classes:
C12M1/00; C12Q1/6851; G01N33/53
Domestic Patent References:
| WO2016135772A1 | 2016-09-01 | |||
| WO2016043170A1 | 2016-03-24 |
Other References:
FURUKAWA, TETSUSHI: "Genetic risk of atrial fibrillation", CARDIOANGIOLOGY, vol. 84, no. 1, 2018, pages 11 - 17
ZHAO, Y. ET AL.: "Post-transcriptional regulation of cardiac sodium channel gene SCN5A expression and function by miR-192-5p", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1852, 2015, pages 2024 - 2034, XP055727349
NATSUME, Y. ET AL.: "Combined Analysis of Human and Experimental Murine Samples Identified Novel Circulating MicroRNAs as Biomarkers for Atrial Fibrillation", CIRC J, vol. 82, 2018, pages 965 - 973, XP055727351
"Prediction of atrial fibrillation occurrence by blood microRNA diagnostic panel' - Opening the way for early detection of 'hidden atrial fibrillation' by a blood test", PRESS NOTIFICATION MATERIALS (RESEARCH RESULTS, 6 February 2018 (2018-02-06), Retrieved from the Internet
SASANO, T.: "Role of microRNA in Atrial Remodeling in HF", SYMPOSIUM LECTURE OF THE ASIA PACIFIC HEART RHYTHM SOCIETY APHRS 2018, 19 October 2018 (2018-10-19), pages 7
SASANO, T. ET AL.: "Approach to Improve Risk Stratification for Atrial Fibrillation by Combination of Genetic Risk and Acquired Risk", PRESENTATION ABSTRACTS OF THE 65TH ANNUAL MEETING OF THE JAPANESE HEART RHYTHM SOCIETY (JHRS2018, 14 July 2018 (2018-07-14)
SASANO, T. ET AL.: "Extracellular nucleotides: Novel players for the pathogenesis of atrial fibrillation", SYMPOSIUM PRESENTATION ABSTRACTS OF THE 2ND JCS COUNCIL FORUM ON BASIC CARDIO VASCULAR RESEARCH, 23 September 2018 (2018-09-23)
ZHAO, Y. ET AL.: "Post-transcriptional regulation of cardiac sodium channel gene SCN5A expression and function by miR-192-5p", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1852, 2015, pages 2024 - 2034, XP055727349
NATSUME, Y. ET AL.: "Combined Analysis of Human and Experimental Murine Samples Identified Novel Circulating MicroRNAs as Biomarkers for Atrial Fibrillation", CIRC J, vol. 82, 2018, pages 965 - 973, XP055727351
"Prediction of atrial fibrillation occurrence by blood microRNA diagnostic panel' - Opening the way for early detection of 'hidden atrial fibrillation' by a blood test", PRESS NOTIFICATION MATERIALS (RESEARCH RESULTS, 6 February 2018 (2018-02-06), Retrieved from the Internet
SASANO, T.: "Role of microRNA in Atrial Remodeling in HF", SYMPOSIUM LECTURE OF THE ASIA PACIFIC HEART RHYTHM SOCIETY APHRS 2018, 19 October 2018 (2018-10-19), pages 7
SASANO, T. ET AL.: "Approach to Improve Risk Stratification for Atrial Fibrillation by Combination of Genetic Risk and Acquired Risk", PRESENTATION ABSTRACTS OF THE 65TH ANNUAL MEETING OF THE JAPANESE HEART RHYTHM SOCIETY (JHRS2018, 14 July 2018 (2018-07-14)
SASANO, T. ET AL.: "Extracellular nucleotides: Novel players for the pathogenesis of atrial fibrillation", SYMPOSIUM PRESENTATION ABSTRACTS OF THE 2ND JCS COUNCIL FORUM ON BASIC CARDIO VASCULAR RESEARCH, 23 September 2018 (2018-09-23)
Attorney, Agent or Firm:
KOYO INTERNATIONAL PATENT FIRM (JP)
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