Title:
METHOD FOR TESTING PULMONARY HYPERTENSION, PATHOLOGICAL ANIMAL MODEL FOR PULMONARY ARTERIAL HYPERTENSION, AND PREVENTIVE OR THERAPEUTIC AGENT FOR PULMONARY HYPERTENSION
Document Type and Number:
WIPO Patent Application WO/2023/090391
Kind Code:
A1
Abstract:
The purpose of the present disclosure is to provide: a method for testing for the presence/absence of hypertension, and the severity or prognosis thereof; a pathological animal model for pulmonary arterial hypertension (PAH); and a preventive or therapeutic agent for hypertension. Provided are: a testing method for hypertension, in which regnase-1 is used as a biomarker; a PAH pathological animal model comprising a non-human animal in which regnase-1 is deleted in alveolar macrophages; and a preventive or therapeutic agent for hypertension, comprising a substance that destroys the 3'UTR stem loop structure in regnase-1 mRNA.
Inventors:
NAKAOKA YOSHIKAZU (JP)
TAKEUCHI OSAMU (JP)
YAKU AI (JP)
TAKEUCHI OSAMU (JP)
YAKU AI (JP)
Application Number:
PCT/JP2022/042690
Publication Date:
May 25, 2023
Filing Date:
November 17, 2022
Export Citation:
Assignee:
NAT CEREBRAL & CARDIOVASCULAR CT (JP)
UNIV KYOTO (JP)
UNIV KYOTO (JP)
International Classes:
C12Q1/68; A01K67/027; A61K31/7088; A61K45/00; A61K48/00; A61P9/12; A61P11/00; C12N15/113; C12Q1/6883; G01N33/15; G01N33/50
Domestic Patent References:
| WO2017002928A1 | 2017-01-05 | |||
| WO2019182055A1 | 2019-09-26 |
Foreign References:
| JP2016056115A | 2016-04-21 |
Other References:
S. AKIRA: "Regnase-1, a Ribonuclease Involved in the Regulation of Immune Responses", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, BIOLOGICAL LABORATORY, COLD SPRING HARBOR, NY, US, vol. 78, no. 0, 1 January 2013 (2013-01-01), US , pages 51 - 60, XP055403306, ISSN: 0091-7451, DOI: 10.1101/sqb.2013.78.019877
YAKU AI, INAGAKI TADAKATSU, ASANO RYOTARO, OKAZAWA MAKOTO, MORI HIROYOSHI, SATO AYUKO, HIA FABIAN, MASAKI TAKESHI, MANABE YUSUKE, : "Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages", CIRCULATION, AMERICAN HEART ASSOCIATION, US, vol. 146, no. 13, 27 September 2022 (2022-09-27), US , pages 1006 - 1022, XP093068565, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.122.059435
YAKU AI, INAGAKI TADAKATSU, ASANO RYOTARO, OKAZAWA MAKOTO, MORI HIROYOSHI, SATO AYUKO, HIA FABIAN, MASAKI TAKESHI, MANABE YUSUKE, : "Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages", CIRCULATION, AMERICAN HEART ASSOCIATION, US, vol. 146, no. 13, 27 September 2022 (2022-09-27), US , pages 1006 - 1022, XP093068565, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.122.059435
Attorney, Agent or Firm:
TANAKA, Junya et al. (JP)
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