Title:
METHOD FOR TREATING FGFR1 MUTATED TUMOR
Document Type and Number:
WIPO Patent Application WO/2020/170355
Kind Code:
A1
Abstract:
Provided are: a medicinal composition for treating an FGFR1 mutated positive brain tumor containing, as an active ingredient, (S)-1-(3-(4-amino-3-((3,5-dimethoxy phenyl)ethynyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)pyrrolidin-1-yl)prop-2-en 1-one or a pharmaceutically accepted salt thereof; and a treatment method using said medicinal composition.
Inventors:
HIRAI HIROSHI (JP)
MIURA AKIHIRO (JP)
MIURA AKIHIRO (JP)
Application Number:
PCT/JP2019/006265
Publication Date:
August 27, 2020
Filing Date:
February 20, 2019
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/519; A61P35/00
Domestic Patent References:
| WO2013108809A1 | 2013-07-25 | |||
| WO2015008844A1 | 2015-01-22 | |||
| WO2015008839A1 | 2015-01-22 | |||
| WO2016159327A1 | 2016-10-06 | |||
| WO2017150725A1 | 2017-09-08 |
Foreign References:
| JP2015508087A | 2015-03-16 | |||
| JP2015500307A | 2015-01-05 |
Other References:
SINGH, DEVENDRA ET AL.: "Transforming Fusion of FGFR and TACC Genes in Human Glioblastoma", SCIENCE, vol. 337, no. 6099, 7 September 2012 (2012-09-07), pages 1231 - 1235, XP055630769
PATANI, HARSHNIRA ET AL.: "Landscape of activating cancer mutations in FGFR kinase and their differential responses to inhibitors in clinical use", ONCOTARGET, vol. 7, no. 17, 16 March 2016 (2016-03-16), pages 24252 - 24268, XP055732346, DOI: 10.18632/oncotarget.8132
PATANI, HARSHNIRA ET AL.: "Landscape of activating cancer mutations in FGFR kinase and their differential responses to inhibitors in clinical use", ONCOTARGET, vol. 7, no. 17, 16 March 2016 (2016-03-16), pages 24252 - 24268, XP055732346, DOI: 10.18632/oncotarget.8132
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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