Title:
A METHOD OF TREATING PATIENTS UNDERGOING PROTEIN REPLACEMENT THERAPY, GENE REPLACEMENT THERAPY, OR OTHER THERAPEUTIC MODALITIES
Document Type and Number:
WIPO Patent Application WO/2011/139379
Kind Code:
A3
Abstract:
The present invention relates, in general, to a method of treating patients undergoing enzyme replacement therapy (ERT) or other therapy involving the administration of a proteinaceous therapeutic agent as well gene replacement therapy with non-viral or viral vectors, or other therapeutic modality or modalities, used alone or in combination, which involve the administration of exogenous substances for potential therapeutic benefit, including, but not limited to DNA vaccines, siRNA, splice-site switching oligomers (SSOs) as well as RNA-based nanoparticles (RNPs) and nanovaccines. The invention further relates to compounds and compositions suitable for use in such methods.
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Inventors:
KISHNANI PRIYA S (US)
BANUGARIA SUHRAD G (US)
KOEBERL DWIGHT D (US)
PRATER SEAN N (US)
BANUGARIA SUHRAD G (US)
KOEBERL DWIGHT D (US)
PRATER SEAN N (US)
Application Number:
PCT/US2011/000800
Publication Date:
March 29, 2012
Filing Date:
May 06, 2011
Export Citation:
Assignee:
UNIV DUKE (US)
KISHNANI PRIYA S (US)
BANUGARIA SUHRAD G (US)
KOEBERL DWIGHT D (US)
PRATER SEAN N (US)
KISHNANI PRIYA S (US)
BANUGARIA SUHRAD G (US)
KOEBERL DWIGHT D (US)
PRATER SEAN N (US)
International Classes:
A61K31/00; A61P3/00; A61P3/10
Foreign References:
US20040167139A1 | 2004-08-26 | |||
US20090110688A1 | 2009-04-30 | |||
US20050002945A1 | 2005-01-06 |
Other References:
REGINA VOGELBACHER ET AL.: "Bortezomib and sirolimus inhibit the chronic active antibody-mediated rejection in experimental renal transplantation in the rat", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 25, 28 April 2010 (2010-04-28), pages 3764 - 3773
Attorney, Agent or Firm:
WILSON, Mary, J. (901 North Glebe Road11th Floo, Arlington VA, US)
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