Title:
METHOD FOR TREATING A POPULATION OF OBJECTS SUSPENDED IN FLUID DROPLETS COMPRISING A TARGET AND RESIDUAL PARTICLE, AND DEVICE FOR CARRYING OUT SAID METHOD
Document Type and Number:
WIPO Patent Application WO/2010/130459
Kind Code:
A3
Abstract:
The present application discloses a method for treating a population of in particular biological objects that are different from each other and suspended in fluid droplets comprising a target and residual particle population, using at least one substrate and one digital microfluidic circuit or controller allowing digital microfluidic droplet displacement, wherein fluid droplets of suitable composition are generated from target and residual particles, and each fluid droplet is analyzed in a first analysis position for the presence of at least one target or residual particle, wherein fluid droplets without target particles are subsequently remove from the substrate by means of a residual particle sump and fluid droplets having at least one target particle or a prescribed minimum number of target particles are fed to a next treatment stage by means of the substrate.
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Inventors:
KIRSTEIN UWE (DE)
LENNARTZ KLAUS (DE)
VAN DEN BOOM THOMAS (DE)
HOSTICKA BEDRICH (DE)
BROCKHERDE WERNER (DE)
BECHEN BENJAMIN (DE)
ERNI DANIEL (DE)
LENNARTZ KLAUS (DE)
VAN DEN BOOM THOMAS (DE)
HOSTICKA BEDRICH (DE)
BROCKHERDE WERNER (DE)
BECHEN BENJAMIN (DE)
ERNI DANIEL (DE)
Application Number:
PCT/EP2010/002977
Publication Date:
January 06, 2011
Filing Date:
May 14, 2010
Export Citation:
Assignee:
UNIV DUISBURG ESSEN (DE)
KIRSTEIN UWE (DE)
LENNARTZ KLAUS (DE)
VAN DEN BOOM THOMAS (DE)
HOSTICKA BEDRICH (DE)
BROCKHERDE WERNER (DE)
BECHEN BENJAMIN (DE)
ERNI DANIEL (DE)
KIRSTEIN UWE (DE)
LENNARTZ KLAUS (DE)
VAN DEN BOOM THOMAS (DE)
HOSTICKA BEDRICH (DE)
BROCKHERDE WERNER (DE)
BECHEN BENJAMIN (DE)
ERNI DANIEL (DE)
International Classes:
G01N15/14; B01L3/00
Domestic Patent References:
| WO2009005680A1 | 2009-01-08 |
Foreign References:
| US20060020371A1 | 2006-01-26 | |||
| US20050249636A1 | 2005-11-10 | |||
| US20080053205A1 | 2008-03-06 | |||
| US20060114296A1 | 2006-06-01 |
Other References:
BOHRINGER K F: "Modeling and controlling parallel tasks in droplet-based microfluidic systems", IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS, vol. 25, no. 2, February 2006 (2006-02-01), IEEE USA, pages 334 - 344, XP002600626, ISSN: 0278-0070, DOI: 10.1109/TCAD.2005.855958
SUNG KWON CHO ET AL: "Creating, Transporting, Cutting, and Merging Liquid Droplets by Electrowetting-Based Actuation for Digital Microfluidic Circuits", JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, vol. 12, no. 1, 1 February 2003 (2003-02-01), IEEE SERVICE CENTER, PISCATAWAY, NJ, US, XP011064831, ISSN: 1057-7157
TAO XU ET AL: "Design-for-Testability for Digital Microfluidic Biochips", VLSI TEST SYMPOSIUM, 2009. VTS '09., 3 May 2009 (2009-05-03), IEEE, PISCATAWAY, NJ, USA, pages 309 - 314, XP031478894, ISBN: 978-0-7695-3598-2
SUNG KWON CHO ET AL: "Creating, Transporting, Cutting, and Merging Liquid Droplets by Electrowetting-Based Actuation for Digital Microfluidic Circuits", JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, vol. 12, no. 1, 1 February 2003 (2003-02-01), IEEE SERVICE CENTER, PISCATAWAY, NJ, US, XP011064831, ISSN: 1057-7157
TAO XU ET AL: "Design-for-Testability for Digital Microfluidic Biochips", VLSI TEST SYMPOSIUM, 2009. VTS '09., 3 May 2009 (2009-05-03), IEEE, PISCATAWAY, NJ, USA, pages 309 - 314, XP031478894, ISBN: 978-0-7695-3598-2
Attorney, Agent or Firm:
GROSSE SCHUMACHER KNAUER VON HIRSCHHAUSEN (Essen, DE)
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