Title:
METHODS AND COMPOSITIONS CONCERNING CANINE INTERLEUKIN 5
Document Type and Number:
WIPO Patent Application WO2001011049
Kind Code:
A3
Abstract:
The present invention provides for the isolation and characterization of canine interleukin-5 (IL-5) and nucleic acid and amino acid sequences of IL-5. More particularly, recombinant DNA molecules encoding for canine interleukin-5 and conservative variants are provided. In other aspects, the invention provides cells comprising the recombinant vectors, and methods for producing canine IL-5 comprising the steps of inserting a transcription regulatory sequence proximal to the IL-5 gene in a cell comprising that gene, and stimulating production of IL-5 through the regulatory sequence.
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Inventors:
GUO HONGLIANG (US)
LAWTON ROBERT (US)
MERMER BRION (US)
AIYAPPA ASHOK P (US)
LAWTON ROBERT (US)
MERMER BRION (US)
AIYAPPA ASHOK P (US)
Application Number:
PCT/US2000/021651
Publication Date:
March 07, 2002
Filing Date:
August 09, 2000
Export Citation:
Assignee:
IDEXX LAB INC (US)
GUO HONGLIANG (US)
LAWTON ROBERT (US)
MERMER BRION (US)
AIYAPPA ASHOK P (US)
GUO HONGLIANG (US)
LAWTON ROBERT (US)
MERMER BRION (US)
AIYAPPA ASHOK P (US)
International Classes:
C07K14/54; C07K16/24; C12N15/24; A61K38/00; A61K39/00; (IPC1-7): C12N15/24; C07K14/54; C07K16/24; A61K39/395; C12N15/11; A61K38/20; C12N5/10; G01N33/68
Domestic Patent References:
| WO1997030156A2 | 1997-08-21 | |||
| WO1999061618A2 | 1999-12-02 |
Other References:
DATABASE EMBL 4 August 1999 (1999-08-04), A.J. GERMAN ET AL: "Canis familiaris Interleukin-5 mRNA, partial cds", XP002170365
P.A. PADRID ET AL: "Sequence and structural analysis of feline interleukin-5 cDNA", AMERICAN JOURNAL OF VETERINARY RESEARCH, vol. 59, no. 10, 1998, pages 1263 - 1269p.a. padrid et al, XP001009828
MERTENS B ET AL: "The nucleotide sequence of the bovine interleukin-5-encoding cDNA", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES,GB,ELSEVIER SCIENCE PUBLISHERS, BARKING, vol. 176, no. 1-2, 17 October 1996 (1996-10-17), pages 273 - 274, XP004070243, ISSN: 0378-1119
CHIHIRO AZUMA ET AL: "Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue", NUCLEIC ACIDS RESEARCH., vol. 14, no. 22, 1986, OXFORD UNIVERSITY PRESS, SURREY., GB, pages 9149 - 9158, XP002170364, ISSN: 0305-1048
P.A. PADRID ET AL: "Sequence and structural analysis of feline interleukin-5 cDNA", AMERICAN JOURNAL OF VETERINARY RESEARCH, vol. 59, no. 10, 1998, pages 1263 - 1269p.a. padrid et al, XP001009828
MERTENS B ET AL: "The nucleotide sequence of the bovine interleukin-5-encoding cDNA", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES,GB,ELSEVIER SCIENCE PUBLISHERS, BARKING, vol. 176, no. 1-2, 17 October 1996 (1996-10-17), pages 273 - 274, XP004070243, ISSN: 0378-1119
CHIHIRO AZUMA ET AL: "Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue", NUCLEIC ACIDS RESEARCH., vol. 14, no. 22, 1986, OXFORD UNIVERSITY PRESS, SURREY., GB, pages 9149 - 9158, XP002170364, ISSN: 0305-1048
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