Title:
METHODS AND COMPOSITIONS FOR IDENTIFYING PEPTIDE APTAMERS CAPABLE OF ALTERING A CELL PHENOTYPE
Document Type and Number:
WIPO Patent Application WO2003040168
Kind Code:
A3
Abstract:
The invention provides methods and compositions for screening and identifying of peptide aptamers that can modulate a cell phenotype and further, can be used for the treatment of a disease involving a misregulated cell phenotype, such as, for example, a cancer. The invention encompasses methods and compositions for producing cyclic peptide aptamers, including peptide aptamers comprising a conotoxin sequence, having improved stability and bioactivity. The invention also provides methods and compositions for improved gene delivery and expression of a peptide aptamer in cell.
Inventors:
BENSON JOHN D (US)
VINCENT SYLVIE MAGALI (US)
BRASHER BRADLEY BRYAN (US)
MIAO ZHENWEI (US)
LAMMING DUDLEY (US)
VINCENT SYLVIE MAGALI (US)
BRASHER BRADLEY BRYAN (US)
MIAO ZHENWEI (US)
LAMMING DUDLEY (US)
Application Number:
PCT/US2002/035584
Publication Date:
September 16, 2004
Filing Date:
November 06, 2002
Export Citation:
Assignee:
ENANTA PHARM INC (US)
BENSON JOHN D (US)
VINCENT SYLVIE MAGALI (US)
BRASHER BRADLEY BRYAN (US)
MIAO ZHENWEI (US)
LAMMING DUDLEY (US)
BENSON JOHN D (US)
VINCENT SYLVIE MAGALI (US)
BRASHER BRADLEY BRYAN (US)
MIAO ZHENWEI (US)
LAMMING DUDLEY (US)
International Classes:
A61K48/00; C07K14/435; C12N15/10; C12N15/867; C12Q1/68; G01N33/50; G01N33/68; (IPC1-7): G01N33/53; C12Q1/68; C12Q1/70
Foreign References:
| US6025485A | 2000-02-15 | |||
| US6153380A | 2000-11-28 | |||
| US20020025537A1 | 2002-02-28 |
Other References:
COLAS P. ET AL: "Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2", NATURE, vol. 380, 11 April 1996 (1996-04-11), pages 548 - 550, XP000904376
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