Title:
PEPTIDES WHICH DELIVER ANTISENSE OLIGONUCLEOTIDES AND DOWNREGULATE PROTEIN EXPRESSION IN CELLS
Document Type and Number:
WIPO Patent Application WO2003040167
Kind Code:
A3
Abstract:
The present invention provides a peptide that can complex with an oligonucleotide, e.g. an antisense oligonucleotide, and deliver it into a cell. The present invention also provides compositions comprising a complex of such a peptide and an oligonucleotide and methods of delivering an oligonucleotide into a cell and of inhibiting protein expression using such compositions. The present invention also provides a method of making such a complex, a method of sensitizing cells to anti-cancer agents such as paclitaxel, and pharmaceutical compositions.
Inventors:
BENIMETSKAYA LUBA
GUZZO-PERNELL NANCY
STEIN CY A
GUZZO-PERNELL NANCY
STEIN CY A
Application Number:
PCT/US2002/034980
Publication Date:
February 19, 2004
Filing Date:
November 01, 2002
Export Citation:
Assignee:
UNIV COLUMBIA (US)
International Classes:
A61K38/17; A61K48/00; C12N15/87; (IPC1-7): C12Q1/68; C07H21/00
Foreign References:
| US5959096A | 1999-09-28 |
Other References:
DATABASE MEDLINE [online] OEHLKE ET AL.: "Cellular uptake of antisense oligonucleotides after complexing or conjugation with cell-penetrating model peptides", XP002965349, Database accession no. 2002424534
DATABASE CA [online] OKUDA T. ET AL.: "Antisense deliver into mitochondria using peptide", XP002965350, Database accession no. 138:126878
DATABASE CA [online] OKUDA T. ET AL.: "Antisense deliver into mitochondria using peptide", XP002965350, Database accession no. 138:126878
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