Title:
METHODS AND COMPOSITIONS RELATED TO MODULATORS OF ANNEXIN AND CARTILAGE HOMEOSTASIS
Document Type and Number:
WIPO Patent Application WO2001047510
Kind Code:
A3
Abstract:
The present invention provides a method of treating a subject with arthritis or an arthritic disease or preventing arthritis or arthritic disease in a subject, comprising administering to the subject a therapeutically effective amount of an agent that attenuates annexin function. Also provided are various methods of screening for agents and genes that increase collagen synthesis, decrease collagen degradation, or reduce or delay apoptosis, and methods of using the identified agents or nucleic acids for attaining or maintaining cartilage homeostasis, promoting cartilage repair, increasing collagen synthesis, decreasing collagen degradation, or reducing or delaying apoptosis. The invention also provides methods of decreasing mineralization of vesicles derived from chondrocytes and of promoting endochondral bone growth using agents that attenuates annexin function. The present invention also provides a composition comprising isolated chondrocytes, an agent that attenuates annexin function, and collagen fragments or other means for challenging chondrocytes, including for example, collagen fragments, collagen peptides, or immune mediators.
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Inventors:
CHUBINSKAYA SUSAN (US)
HUTCHINS JEFF (US)
MOLLENHAUER JUERGEN (DE)
TAVARES FRANCIS X (US)
WORLEY JENNINGS F (US)
THOMSON STEPHEN A (US)
HUTCHINS JEFF (US)
MOLLENHAUER JUERGEN (DE)
TAVARES FRANCIS X (US)
WORLEY JENNINGS F (US)
THOMSON STEPHEN A (US)
Application Number:
PCT/US2000/034936
Publication Date:
February 21, 2002
Filing Date:
December 21, 2000
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
RUSH PRESBYTERIAN ST LUKE (US)
CHUBINSKAYA SUSAN (US)
HUTCHINS JEFF (US)
MOLLENHAUER JUERGEN (DE)
TAVARES FRANCIS X (US)
WORLEY JENNINGS F (US)
THOMSON STEPHEN A (US)
RUSH PRESBYTERIAN ST LUKE (US)
CHUBINSKAYA SUSAN (US)
HUTCHINS JEFF (US)
MOLLENHAUER JUERGEN (DE)
TAVARES FRANCIS X (US)
WORLEY JENNINGS F (US)
THOMSON STEPHEN A (US)
International Classes:
A61K31/00; A61K31/55; A61K31/5513; A61K31/553; A61K31/554; A61K31/7088; A61K45/00; A61K48/00; A61K49/00; A61P3/14; A61P19/02; A61P19/08; A61P43/00; C07D243/24; C07D403/12; C07D417/12; G01N33/15; G01N33/50; G01N33/68; (IPC1-7): A61K31/5513; A61K31/553; A61K31/554; A61P19/02
Foreign References:
| US5004741A | 1991-04-02 | |||
| US5416066A | 1995-05-16 |
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