COMPOSITION FOR THE TREATMENT DIABETES MELLITUS CONTAINING AN INSULINE SENSITIZER AND AGENT USED IN THE TREATMENT OF CARDIAC CONDITIONS

Title:

COMPOSITION FOR THE TREATMENT DIABETES MELLITUS CONTAINING AN INSULINE SENSITIZER AND AGENT USED IN THE TREATMENT OF CARDIAC CONDITIONS

Document Type and Number:

WIPO Patent Application WO2001047509

Kind Code:

A3

Abstract:

A method for the treatment of diabetes mellitus, especially Type II diabetes and the cardiac conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an effective non-toxic and pharmaceutically acceptable amount of an insulin sensitiser, such as Compound (I), and an agent used in the treatment of the cardiac conditions associated with diabetes mellitus.

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Inventors:

BUCKINGHAM ROBIN EDWARD (GB)

Application Number:

PCT/GB2000/005006

Publication Date:

September 12, 2002

Filing Date:

December 22, 2000

Export Citation:

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Assignee:

SMITHKLINE BEECHAM PLC (GB)
BUCKINGHAM ROBIN EDWARD (GB)

International Classes:

A61K31/00; A61K45/06; A61P3/10; A61P9/00; (IPC1-7): A61K45/06; A61P3/10

Domestic Patent References:

WO2000027434A1

2000-05-18

Foreign References:

EP0861666A2	1998-09-02
US5965584A	1999-10-12
EP0930076A1	1999-07-21

Other References:

SHIMOYAMA, MASAKI ET AL: "Hemodynamic basis for the acute cardiac effects of troglitazone in isolated perfused rat hearts.", DIABETES, (MARCH, 1999) VOL. 48, NO. 3, PP. 609-615., XP001035237
DAGOGO-JACK S ET AL: "PATHOPHYSIOLOGY OF TYPE 2 DIABETES AND MODES OF ACTION OF THERAPEUTIC INTERVENTIONS", ARCHIVES OF INTERNAL MEDICINE, XX, XX, vol. 157, no. 16, 8 September 1997 (1997-09-08), pages 1802 - 1817, XP000872498
HOSOKAWA, M. ET AL: "Troglitazone inhibits bicarbonate secretion in rat and human duodenum", J. PHARMACOL. EXP. THER. (1999), 290(3), 1080-1084, XP008002057

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