Title:
METHODS FOR DESIGNING SPECIFIC ION CHANNEL BLOCKERS
Document Type and Number:
WIPO Patent Application WO1999048927
Kind Code:
A9
Abstract:
The present invention relates to a method of designing an ion channel blocker for an ion channel which includes providing an ion channel having an external vestibule portion and raising an antibody, binding portion, probe, or ligand specific to the external vestibule portion of the ion channel, where the antibody, binding portion, probe, or ligand inhibits ion transport through the ion channel. The present invention further relates to a method of inhibiting ion transport through an ion channel, a method for screening a drug for effectiveness as an ion channel blocker, and an antibody, binding portion, probe, or ligand.
Inventors:
HUANG XIN-YUN
Application Number:
PCT/US1999/006019
Publication Date:
January 20, 2000
Filing Date:
March 19, 1999
Export Citation:
Assignee:
CORNELL RES FOUNDATION INC (US)
International Classes:
C07K14/705; C07K16/28; (IPC1-7): C07K16/44; A61K39/395; C07K14/705; G01N33/53
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