Title:
METHODS FOR IDENTIFYING OR CHARACTERISING A SITE BASED ON THE THERMODYNAMIC PROPERTIES OF NUCLEIC ACIDS
Document Type and Number:
WIPO Patent Application WO1999042621
Kind Code:
A3
Abstract:
The invention relates to nucleic acid sequences, and, in particular, to methods for identifying or designing structural and/or energetic characteristics of nucleic acids, and proteins which are encoded by the nucleic acids.
Inventors:
LANE MICHAEL J
BENIGHT ALBERT S
FALDASZ BRIAN D
BENIGHT ALBERT S
FALDASZ BRIAN D
Application Number:
PCT/US1999/003754
Publication Date:
March 16, 2000
Filing Date:
February 19, 1999
Export Citation:
Assignee:
TM TECHNOLOGIES INC (US)
International Classes:
C12Q1/68; G16B20/00; G16B20/30; G16B25/10; G16B30/10; (IPC1-7): C12Q1/68
Domestic Patent References:
| WO1993000446A1 | 1993-01-07 | |||
| WO1995000665A1 | 1995-01-05 | |||
| WO1999032664A1 | 1999-07-01 | |||
| WO1998037242A1 | 1998-08-27 |
Other References:
DATABASE CHEMICAL ABSTRACTS 18 August 1997 (1997-08-18), SCZAKIEL G. ET AL.: "Computer-aided calculation of the local folding potential of target RNA and its use for ribozyme design", XP002110004
DATABASE CHEMICAL ABSTRACTS SZAKIEL G. ET AL.: "Computer-aided search for effective antisense RNA target sequences of the human immunodeficiency virus type 1", XP002110005
DATABASE MEDLINE us national library of medicine; HYNDMAN D. ET AL.: "Software to detewrmine optimal oligonucleotide sequences based on hybridization simulation data", XP002110006
BRUICE T W ET AL: "Control of complexity constraints on combinatorial screening for preferred oligonucleotide hybridisation sites on structured RNA", BIOCHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. EASTON, PA, vol. 36, no. 16, pages 5004-5019-5019, XP002110003, ISSN: 0006-2960
DATABASE CHEMABS Chemical Abstracts Service, Columbus, Ohio, US; STULL, R.A. ET AL.: "Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices", XP002110007
DATABASE CHEMICAL ABSTRACTS SZAKIEL G. ET AL.: "Computer-aided search for effective antisense RNA target sequences of the human immunodeficiency virus type 1", XP002110005
DATABASE MEDLINE us national library of medicine; HYNDMAN D. ET AL.: "Software to detewrmine optimal oligonucleotide sequences based on hybridization simulation data", XP002110006
BRUICE T W ET AL: "Control of complexity constraints on combinatorial screening for preferred oligonucleotide hybridisation sites on structured RNA", BIOCHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. EASTON, PA, vol. 36, no. 16, pages 5004-5019-5019, XP002110003, ISSN: 0006-2960
DATABASE CHEMABS Chemical Abstracts Service, Columbus, Ohio, US; STULL, R.A. ET AL.: "Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices", XP002110007
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