Title:
METHODS FOR IDENTIFYING G-PROTEIN COUPLED RECEPTORS ASSOCIATED WITH DISEASES
Document Type and Number:
WIPO Patent Application WO2002052047
Kind Code:
A3
Abstract:
The present invention describes a method for isolating novel G-protein coupled receptors (GPCRs) whose expression is associated with disease states. The invention provides polynucleotide and polypeptide sequences whose expression is associated with neurodegenerative diseases and cancer. The invention also provides evidence of novel G-protein coupled receptors (GPCRs) related polynucleotide sequences whose expression level is associated with Parkinson's disease, Alzheimer's disease and leukemia. The present invention provides methods for identifying GPCR polypeptides associated with diseases and provides diagnostic compositions and methods for the detection of diseases.
Inventors:
YU ZAILIN (US)
PENG ZAOYUAN (US)
WILEY ANDREW (US)
HU QIANJIN (US)
PENG ZAOYUAN (US)
WILEY ANDREW (US)
HU QIANJIN (US)
Application Number:
PCT/US2001/050242
Publication Date:
February 12, 2004
Filing Date:
December 21, 2001
Export Citation:
Assignee:
MERGEN LTD (US)
YU ZAILIN (US)
PENG ZAOYUAN (US)
WILEY ANDREW (US)
HU QIANJIN (US)
YU ZAILIN (US)
PENG ZAOYUAN (US)
WILEY ANDREW (US)
HU QIANJIN (US)
International Classes:
C07K14/705; C12Q1/68; C12Q1/6883; (IPC1-7): C12Q1/68; C12N5/10; C07K16/28; C07K14/72
Domestic Patent References:
| WO2000064941A2 | 2000-11-02 | |||
| WO2000031258A2 | 2000-06-02 |
Other References:
LOHSE M J ET AL: "Mechanisms of beta-adrenergic receptor desensitization: From molecular biology to heart failure.", BASIC RESEARCH IN CARDIOLOGY, vol. 91, no. SUPPL. 2, 1996, pages 29 - 34, XP009013860, ISSN: 0300-8428
COUGHLIN SHAUN R: "Expanding horizons for receptors coupled to G proteins: Diversity and disease.", CURRENT OPINION IN CELL BIOLOGY, vol. 6, no. 2, 1994, pages 191 - 197, XP009013714, ISSN: 0955-0674
WINKLES JEFFREY A ET AL: "Endothelin-1 and endothelin receptor mRNA expression in normal and atherosclerotic human arteries.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 191, no. 3, 1993, pages 1081 - 1088, XP002248168, ISSN: 0006-291X
DATABASE EMBL [online] 3 February 2000 (2000-02-03), HATTORI M ET AL.: "Homo sapiens genomic DNA, chromosome 11q12 clone:CMB9-97K3", XP002248169, accession no. EBI Database accession no. AP001112
DATABASE EMBL [online] 15 March 2000 (2000-03-15), BIRREN B ET AL.: "Homo sapiens chromosome 13 clone RP11-165L6 map 13", XP002248170, retrieved from AC025497 accession no. EBI
DATABASE EMBL [online] 16 August 2000 (2000-08-16), BOUGUELERET L. ET AL.: "Olfactory receptor protein OLF-9", XP002248171, accession no. EBI Database accession no. AAY83394
STADEL J M ET AL: "Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 18, no. 11, 1 November 1997 (1997-11-01), pages 430 - 437, XP004099345, ISSN: 0165-6147
ALEWIJNSE ASTRID E ET AL: "The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H2 receptor", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 57, no. 5, May 2000 (2000-05-01), pages 890 - 898, XP002193305, ISSN: 0026-895X
MIRNICS X ET AL: "DISEASE-SPECIFIC CHANGES IN REGULATOR OF G-PROTEIN SIGNALING 4 (RGS4) EXPRESSION IN SCHIZOPHRENIA", MOLECULAR PSYCHIATRY, BASINGSTOKE, GB, vol. 6, no. 3, 2001, pages 293 - 301, XP001133840, ISSN: 1359-4184
DATABASE EMBL [online] 20 September 2001 (2001-09-20), ZOZULYA S.: "Human cDNA encoding olfactory receptor AOLFR17", XP002248172, accession no. EBI Database accession no. AAS42225
DATABASE EMBL [online] 6 September 2001 (2001-09-06), TAUPIER R.J. ET AL.: "Sequence 9 from patent WO0159113", XP002248173, accession no. EBI Database accession no. AX214095
COUGHLIN SHAUN R: "Expanding horizons for receptors coupled to G proteins: Diversity and disease.", CURRENT OPINION IN CELL BIOLOGY, vol. 6, no. 2, 1994, pages 191 - 197, XP009013714, ISSN: 0955-0674
WINKLES JEFFREY A ET AL: "Endothelin-1 and endothelin receptor mRNA expression in normal and atherosclerotic human arteries.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 191, no. 3, 1993, pages 1081 - 1088, XP002248168, ISSN: 0006-291X
DATABASE EMBL [online] 3 February 2000 (2000-02-03), HATTORI M ET AL.: "Homo sapiens genomic DNA, chromosome 11q12 clone:CMB9-97K3", XP002248169, accession no. EBI Database accession no. AP001112
DATABASE EMBL [online] 15 March 2000 (2000-03-15), BIRREN B ET AL.: "Homo sapiens chromosome 13 clone RP11-165L6 map 13", XP002248170, retrieved from AC025497 accession no. EBI
DATABASE EMBL [online] 16 August 2000 (2000-08-16), BOUGUELERET L. ET AL.: "Olfactory receptor protein OLF-9", XP002248171, accession no. EBI Database accession no. AAY83394
STADEL J M ET AL: "Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 18, no. 11, 1 November 1997 (1997-11-01), pages 430 - 437, XP004099345, ISSN: 0165-6147
ALEWIJNSE ASTRID E ET AL: "The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H2 receptor", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 57, no. 5, May 2000 (2000-05-01), pages 890 - 898, XP002193305, ISSN: 0026-895X
MIRNICS X ET AL: "DISEASE-SPECIFIC CHANGES IN REGULATOR OF G-PROTEIN SIGNALING 4 (RGS4) EXPRESSION IN SCHIZOPHRENIA", MOLECULAR PSYCHIATRY, BASINGSTOKE, GB, vol. 6, no. 3, 2001, pages 293 - 301, XP001133840, ISSN: 1359-4184
DATABASE EMBL [online] 20 September 2001 (2001-09-20), ZOZULYA S.: "Human cDNA encoding olfactory receptor AOLFR17", XP002248172, accession no. EBI Database accession no. AAS42225
DATABASE EMBL [online] 6 September 2001 (2001-09-06), TAUPIER R.J. ET AL.: "Sequence 9 from patent WO0159113", XP002248173, accession no. EBI Database accession no. AX214095
Download PDF: