Title:
METHODS FOR IDENTIFYING MODULATORS FOR BALANCE RELATED DISORDERS
Document Type and Number:
WIPO Patent Application WO2001040519
Kind Code:
A8
Abstract:
The present invention provides a method of identifying a compound that modulates a mammalian vestibular system. The method consists of administering a test compound to an invertebrate, and measuring a geotactic behavior of the invertebrate, where a compound tht modulates the geotactic behavior of said invertebrate is characterized as a compound that modulates a mammalian vestibular system. The invention also provides a method of identifying a gene that modulates a mammalian vestibular system consisting of obtaining a first and a second strain of an invertebrate; subjecting the first and second invertebrate strains to conditions in which the first strain exhibits a geotactic behavior different than a geotactic behavior exhibited by the second strain; measuring gene expression levels in the first and second strains, and identifying one or more genes that are differentially expressed in the first strain relative to the second strain, whereby a mammalian gene having substantially the same nucleic acid sequence as the one or more differentially expressed genes modulates the mammalian vestibular system.
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Inventors:
GREENSPAN RALPH J (US)
Application Number:
PCT/US2000/032639
Publication Date:
October 23, 2003
Filing Date:
December 01, 2000
Export Citation:
Assignee:
NEUROSCIENCES RES FOUND (US)
GREENSPAN RALPH J (US)
GREENSPAN RALPH J (US)
International Classes:
A61K38/00; A61K49/00; A61P27/00; C07K14/435; C07K16/18; C12N15/12; C12Q1/68; G01N33/50; (IPC1-7): G01N33/50; C12Q1/68; A61P27/00; C12N15/12; C07K14/435; C07K16/18
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