METHODS FOR IMPROVEMENT OF LUNG FUNCTION USING TGF-beta INHIBITORS

Title:

METHODS FOR IMPROVEMENT OF LUNG FUNCTION USING TGF-beta INHIBITORS

Document Type and Number:

WIPO Patent Application WO2004010929

Kind Code:

A3

Abstract:

The invention concerns methods for improvement of lung function by administering non-peptide small molecule inhibitors of TGF-beta specifically binding to the type I TGF-beta receptor (TGFbeta-R1). Preferably, the inhibitors are quinazoline derivatives.

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Inventors:

LI ZHIHE (US)
LIU DAVID Y (US)
MA JING YING (US)
PROTTER ANDREW (US)
SCHREINER GEORGE F (US)
TRAN THOMAS-TOAN (US)

Application Number:

PCT/US2003/023240

Publication Date:

December 01, 2005

Filing Date:

July 23, 2003

Export Citation:

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Assignee:

SCIOS INC (US)
LI ZHIHE (US)
LIU DAVID Y (US)
MA JING YING (US)
PROTTER ANDREW (US)
SCHREINER GEORGE F (US)
TRAN THOMAS-TOAN (US)

International Classes:

A61K31/00; A61K31/34; A61K31/381; A61K31/40; A61K31/4035; A61K31/498; A61K31/4985; A61K31/505; A61K31/506; A61K31/517; A61K31/519; A61K31/53; A61K31/5355; (IPC1-7): A61K31/53; A61K31/435; C07D239/00

Foreign References:

US20040127575A1	2004-07-01
US20040038856A1	2004-02-26
US6476031B1	2002-11-05
US20030166633A1	2003-09-04
US4366189A	1982-12-28

Other References:

LEESE ET AL: "The synthesis of 4-aminopteridines as potential antimetabolites", 27 May 1958 (1958-05-27), pages 4105, XP008095241
See also references of EP 1575506A4

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