Title:
METHODS OF INCREASING ENDOGENOUS ERYTHROPOIETIN (EPO)
Document Type and Number:
WIPO Patent Application WO2003053997
Kind Code:
A3
Abstract:
The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.
Inventors:
KLAUS STEPHEN J (US)
LIN AL Y (US)
NEFF THOMAS B (US)
WANG QINGJIAN (US)
GUENZLER-PUKALL VOLKMAR (US)
AREND MICHAEL P (US)
FLIPPIN LEE A (US)
LIN AL Y (US)
NEFF THOMAS B (US)
WANG QINGJIAN (US)
GUENZLER-PUKALL VOLKMAR (US)
AREND MICHAEL P (US)
FLIPPIN LEE A (US)
Application Number:
PCT/US2002/039163
Publication Date:
June 17, 2004
Filing Date:
December 06, 2002
Export Citation:
Assignee:
FIBROGEN INC (US)
KLAUS STEPHEN J (US)
LIN AL Y (US)
NEFF THOMAS B (US)
WANG QINGJIAN (US)
GUENZLER-PUKALL VOLKMAR (US)
AREND MICHAEL P (US)
FLIPPIN LEE A (US)
KLAUS STEPHEN J (US)
LIN AL Y (US)
NEFF THOMAS B (US)
WANG QINGJIAN (US)
GUENZLER-PUKALL VOLKMAR (US)
AREND MICHAEL P (US)
FLIPPIN LEE A (US)
International Classes:
A61K31/00; A61K31/44; A61K31/4418; G01N33/50; A61K31/47; A61K31/472; A61K31/4745; A61K31/496; A61K31/555; A61K31/63; A61K33/26; A61K38/00; A61K38/17; A61K38/22; A61K45/00; A61K45/06; A61P1/04; A61P1/16; A61P3/10; A61P7/06; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P17/02; A61P25/00; A61P25/08; A61P43/00; C07K14/47; C07K14/505; C12N9/99; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; (IPC1-7): C12N15/09; C12Q1/56; C12Q1/34
Other References:
GUNZLER, V ET AL: "Time-dependent inactivatiobn of chick-embryo prolyl 4-hydroxylase by cournalic acid", BIOCHEM. JOURNAL, vol. 242, 1987, pages 163 - 169, XP002975232
SAMIMI, A ET AL: "Mechanism of inhibition of lysyl hydroxylase activity by the organophosphates malathion and malaoxon", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 176, 2001, pages 181 - 186, XP002975233
SAMIMI, A ET AL: "Mechanism of inhibition of lysyl hydroxylase activity by the organophosphates malathion and malaoxon", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 176, 2001, pages 181 - 186, XP002975233
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