METHODS FOR MAKING HARDLY SOLUBLE MEDICINE AMORPHOUS

Title:

METHODS FOR MAKING HARDLY SOLUBLE MEDICINE AMORPHOUS

Document Type and Number:

WIPO Patent Application WO/1997/006781

Kind Code:

A1

Abstract:

A process for preparing a solid dispersion of a hardly soluble medicine which comprises heating the hardly soluble medicine, an amorphism-inducing agent and an amorphism stabilizer or mechanochemically treating the same; and a process for producing a solid dispersion of a hardly soluble medicine which comprises high-frequency heating the hardly soluble medicine and an amorphism stabilizer. These processes make it possible to make hardly soluble medicines amorphous at a temperature lower than those employed in the conventional methods. The solid dispersions of the amorphous hardly soluble medicines thus obtained have an improved mucosal or rectal adsorption rate, which makes it possible to elevate their bioavailability.

Inventors:

MIYAMOTO MISAO (JP)
ODA TOSHIHISA (JP)

Application Number:

PCT/JP1996/002246

Publication Date:

February 27, 1997

Filing Date:

August 08, 1996

Export Citation:

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Assignee:

NISSAN CHEMICAL IND LTD (JP)
MIYAMOTO MISAO (JP)
ODA TOSHIHISA (JP)

International Classes:

A61K9/14; A61K9/00; (IPC1-7): A61K9/00

Foreign References:

JPH0267229A	1990-03-07
JPS63115815A	1988-05-20

Other References: