Title:
METHODS FOR PREPARING ANTIBODY-DRUG CONJUGATES
Document Type and Number:
WIPO Patent Application WO/2024/046455
Kind Code:
A1
Abstract:
Provided relates to antibody-drug conjugates (ADCs) having a uniform drug-to-antibody ratio of about 4, and methods of making the ADCs thereof. In some embodiments, the ADCs include an antibody (e.g., human IgG1), whose heavy chains (e.g., Fab or Fc regions), light chains, and/or hinge region include one or more cysteine mutations.
Inventors:
HAN YANFEI (CN)
SHANG CHENGZHANG (CN)
LIU BAIHONG (CN)
YANG YI (CN)
SHEN YUELEI (CN)
SHANG CHENGZHANG (CN)
LIU BAIHONG (CN)
YANG YI (CN)
SHEN YUELEI (CN)
Application Number:
PCT/CN2023/116426
Publication Date:
March 07, 2024
Filing Date:
September 01, 2023
Export Citation:
Assignee:
BIOCYTOGEN PHARMACEUTICALS BEIJING CO LTD (CN)
International Classes:
A61K47/68; A61K39/395; A61P35/00; C07K16/30
Domestic Patent References:
| WO2023143343A1 | 2023-08-03 | |||
| WO2015031698A1 | 2015-03-05 | |||
| WO2022159984A1 | 2022-07-28 | |||
| WO2016166301A1 | 2016-10-20 | |||
| WO2016064749A2 | 2016-04-28 |
Other References:
CHENGZHANG SHANG; LIU YANG; JIYONG ZHANG; YANFEI HAN; ZHUOLIN LI; ZHENYAN HAN; JUN LI; YING MENG; GAO AN; HAO YANG; WENQIAN AN; LE: "Abstract 4256: YH012, a novelbispecific anti-HER2 and TROP2antibody-drug conjugate, exhibitspotent antitumor efficacy", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 82, no. 12, Suppl., 15 July 2022 (2022-07-15), US, pages 4256, XP009552928, ISSN: 0008-5472, DOI: 10.1158/1538-7445.AM2022-4256
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