Title:
HETEROARYL-SUBSTITUTED PYRIDOPYRROLIDONE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/046454
Kind Code:
A1
Abstract:
The present application relates to a heteroaryl-substituted pyridopyrrolidone derivative, and a pharmaceutical composition and the use thereof. The heteroaryl-substituted pyridopyrrolidone derivative has a structure as shown in formula (I). The compound of the present application has a relatively high selective inhibitory activity on PI3Kγ and an improved in-vivo pharmacokinetic activity, and has practical value.
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Inventors:
SUN HONGPENG (CN)
XU FENG (CN)
WANG HAILONG (CN)
XI BAOXIN (CN)
TONG ZHONGAN (CN)
MA QIAN (CN)
LI XIN (CN)
XU FENG (CN)
WANG HAILONG (CN)
XI BAOXIN (CN)
TONG ZHONGAN (CN)
MA QIAN (CN)
LI XIN (CN)
Application Number:
PCT/CN2023/116425
Publication Date:
March 07, 2024
Filing Date:
September 01, 2023
Export Citation:
Assignee:
SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN)
YANGTZE RIVER PHARM GROUP CO (CN)
YANGTZE RIVER PHARM GROUP CO (CN)
International Classes:
C07D471/04; A61K31/427; A61K31/4985; A61P3/00; A61P29/00; A61P35/00; C07D487/04
Domestic Patent References:
| WO2023165551A1 | 2023-09-07 |
Foreign References:
| CN114025756A | 2022-02-08 | |||
| CN114258393A | 2022-03-29 | |||
| CN114206332A | 2022-03-18 | |||
| CN107001348A | 2017-08-01 | |||
| CN108779110A | 2018-11-09 |
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
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