Title:
METHODS OF PREVENTING AND TREATING FLAVIVIRUS INFECTION IN ANIMALS
Document Type and Number:
WIPO Patent Application WO2003063725
Kind Code:
A3
Abstract:
The invention provides methods of preventing and treating flavivirus infection in animals.
Inventors:
MONATH THOMAS P (US)
ARROYO JUAN (US)
ARROYO JUAN (US)
Application Number:
PCT/US2002/033795
Publication Date:
October 30, 2003
Filing Date:
October 21, 2002
Export Citation:
Assignee:
ACAMBIS INC (US)
MONATH THOMAS P (US)
ARROYO JUAN (US)
MONATH THOMAS P (US)
ARROYO JUAN (US)
International Classes:
A61K39/12; A61P31/14; C07K14/18; C12N7/00; C12N15/31; C12N15/33; C12N15/40; (IPC1-7): A61K39/12; A61K39/295; C12N7/00; C12P21/06
Domestic Patent References:
| WO1998037911A1 | 1998-09-03 | |||
| WO1993006214A1 | 1993-04-01 |
Foreign References:
| US6184024B1 | 2001-02-06 |
Other References:
GUIRAKHOO ET AL.: "immunogenicity, genetic stability and protective efficacy of a recombinant, chimeric yellow fever-Japanese encephalitis virus (chimerivax-je) as a live, attenuated vaccine candidate against Japanese encephalitis", VIROLOGY, vol. 257, May 1999 (1999-05-01), pages 363 - 372, XP004439948
MONATH ET AL.: "West Nile virus vaccine", CURRENT DRUG TARGETS-INFECTIOUS DISORDERS, vol. 1, no. 1, May 2001 (2001-05-01), pages 37 - 50, XP002967300
GUIRAKHOO ET AL.: "Construction, safety and immunogenicity in nonhuman primates of a chimeric yellow fever-dengue virus tetravalent vaccine", JOURNAL OF VIROLOGY, vol. 75, no. 16, August 2001 (2001-08-01), pages 7290 - 7304, XP002961663
ARROYO ET AL.: "Molecular basis for attenuation of neurovirulence of a yellow fever virus/Japanese encephalitis virus chimera vaccine (chimerivax-je)", JOURNAL OF VIROLOGY, vol. 75, no. 2, January 2001 (2001-01-01), pages 934 - 942, XP002967301
CHAMBERS ET AL.: "Yellow fever/Japanese encephalitis chimeric viruses: construction and biological properties", JOURNAL OF VIROLOGY, vol. 73, no. 4, April 1999 (1999-04-01), pages 3095 - 3101, XP002139409
ARROYO ET AL.: "Yellow fever vector live-virus vaccines: West Nile virus vaccine developments", TRENDS IN MOLECULAR MEDICINE, vol. 7, no. 8, August 2001 (2001-08-01), pages 350 - 354, XP002239874
MONATH ET AL.: "West Nile virus vaccine", CURRENT DRUG TARGETS-INFECTIOUS DISORDERS, vol. 1, no. 1, May 2001 (2001-05-01), pages 37 - 50, XP002967300
GUIRAKHOO ET AL.: "Construction, safety and immunogenicity in nonhuman primates of a chimeric yellow fever-dengue virus tetravalent vaccine", JOURNAL OF VIROLOGY, vol. 75, no. 16, August 2001 (2001-08-01), pages 7290 - 7304, XP002961663
ARROYO ET AL.: "Molecular basis for attenuation of neurovirulence of a yellow fever virus/Japanese encephalitis virus chimera vaccine (chimerivax-je)", JOURNAL OF VIROLOGY, vol. 75, no. 2, January 2001 (2001-01-01), pages 934 - 942, XP002967301
CHAMBERS ET AL.: "Yellow fever/Japanese encephalitis chimeric viruses: construction and biological properties", JOURNAL OF VIROLOGY, vol. 73, no. 4, April 1999 (1999-04-01), pages 3095 - 3101, XP002139409
ARROYO ET AL.: "Yellow fever vector live-virus vaccines: West Nile virus vaccine developments", TRENDS IN MOLECULAR MEDICINE, vol. 7, no. 8, August 2001 (2001-08-01), pages 350 - 354, XP002239874
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