Title:
METHODS OF REDUCING HYPOGLYCEMIC EPISODES IN THE TREATMENT OF DIABETES MELLITUS
Document Type and Number:
WIPO Patent Application WO2003105768
Kind Code:
A3
Abstract:
The present invention provides compositions and methods for reducing hypoglycemic episodes experienced by a subject in need of treatment for diabetes mellitus, said method comprising orally administering an amount of an insulin polypeptide-oligomer conjugate to the subject, wherein: i) the amount of the insulin polypeptide-oligomer conjugate reduces the number and/or severity of hypoglycemic episodes experienced by the subject during a given time period when compared with the number and/or severity of hypoglycemic episodes that would have been experienced during a similar time period by the subject or by subjects in a control group parenterally administered insulin or an insulin analog in an amount that provides a substantially equivalent level of glycemic control; and ii) the oligomer of the insulin polypeptide-oligomer conjugate comprises a hydrophilic moiety and a lipophilic moiety.
Inventors:
STILL JAMES GORDON (US)
KOSUTIC GORDANA (US)
KOSUTIC GORDANA (US)
Application Number:
PCT/US2003/018763
Publication Date:
March 11, 2004
Filing Date:
June 13, 2003
Export Citation:
Assignee:
NOBEX CORP (US)
STILL JAMES GORDON (US)
KOSUTIC GORDANA (US)
STILL JAMES GORDON (US)
KOSUTIC GORDANA (US)
International Classes:
A61K47/48; (IPC1-7): A61K38/28
Foreign References:
| US20030083232A1 | 2003-05-01 | |||
| US20030050228A1 | 2003-03-13 | |||
| US6309633B1 | 2001-10-30 |
Other References:
LIU ET AL.: "Glucose-induced release of glycosylpoly(ethylene glycol) insulin bound to a soluble conjugate of concanavalin A", BIOCONJUGATE CHEM., vol. 8, 1997, pages 664 - 672, XP002972016
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