Title:
METHODS OF THERAPY FOR B-CELL MALIGNANCIES USING ANTAGONIST ANTI-CD40 ANTIBODIES
Document Type and Number:
WIPO Patent Application WO2002028481
Kind Code:
A9
Abstract:
Methods of therapy for B-cell malignancies are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity when the antibody binds a CD40 antigen on a normal human B cell, exhibits antagonist activity when the antibody binds a CD40 antigen on a malignant human B cell, and can exhibit antagonist activity when the antibody binds a CD40 antigen on a normal human B cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of malignant human B cells.
Inventors:
CHU KETING (US)
MASUOKA LORIANNE (US)
MASUOKA LORIANNE (US)
Application Number:
PCT/US2001/030963
Publication Date:
July 03, 2003
Filing Date:
October 02, 2001
Export Citation:
Assignee:
CHIRON CORP (US)
CHU KETING (US)
MASUOKA LORIANNE (US)
CHU KETING (US)
MASUOKA LORIANNE (US)
International Classes:
A61K39/395; A61P1/04; A61P17/06; C12N15/09; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61P43/00; C07K16/18; C07K16/28; C07K16/30; C12N15/13; C12P21/08; (IPC1-7): A61P35/00; A61K39/395
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